Allies Voice: What's in your bottle of "insulin"?
Ever wonder what's in a bottle of insulin? Don't believe the hype. Trusting individuals with insulin-dependent diabetes would bet their bottom-dollar it's insulin, right? In fact, what lurks beneath the designer label of patented formulas is a ruse of hypoglycemic agents commingled with preservatives, hazardous materials and fillers. Ready or not - here's the truth behind what's in a bottle of short-acting insulin analogues...
With the insight and assistance of a good friend, I was privy to the analysis of insulin analogues like Humalog, Apidra, and NovoLog. Big Pharmaceutical companies have been trumpeting the extraordinary glucose suppression of insulin analogues but at what cost?
What is an insulin analogue anyway? It sure ain't your father's insulin! An insulin analog is an altered form of insulin, different from the insulin secreted by the human pancreas. This means is does lower blood glucose, but without any of the inherent safety designs Mother Nature intended to prevent complications of diabetes (i.e., C-peptide).
Through genetic engineering of the underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics. Anybody feel like a science experiment yet?
Lest we not forget - genetic engineering costs big money. As the old saying goes time is money, so far be it from our trusting engineers to let a vial go to waste. Let me introduce you to a couple of star players in insulin that you must take into consideration with great caution: m-Cresol and methyl p-hydroxybenzoate.
Meta Cresol has been used for decades in insulin preparations, however the levels of m-Cresol have been silently creeping up, along with: costs, complications and better hemoglobin A1c levels. Wasn't the promise of rDNA insulin more affordable insulin? Didn't the insulin manufacturers promise if we control our blood glucose we would deter the onset of complications? Well, it looks like the majority has kept up with their end of the bargain. What's the holdup with the reduction in price and complications? I wonder if the preservatives are the fly in the proverbial ointment.
These insulin preservatives tend to shy away from the spotlight (even though they account for nearly as much as the insuliln analogue per milliliter. Insulins of yesteryear didn't have nearly as much m-Cresol as our beloved insulin analogues.
Each milliliter of Eli Lilly (NYSE: LLY) Humalog injection contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg m-Cresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. Hydrochloric acid 10% and/or sodium hydroxide 10% may be added to adjust pH.
With how many of the above mentioned ingredients are you familiar? Moving on…
NovoLog, Novo Nordisk A/S (NYSE: NVO) is a sterile, aqueous, clear, and colorless solution, that contains insulin aspart (B28 asp regular human insulin analog) 100 Units/mL, glycerin 16 mg/mL, phenol 1.50 mg/mL, m-Cresol 1.72 mg/mL, zinc 19.6 µg/mL, disodium hydrogen phosphate dihydrate 1.25 mg/mL, and sodium chloride 0.58 mg/mL. NovoLog has a pH of 7.2-7.6. Hydrochloric acid 10% and/or sodium hydroxide 10% may be added to adjust pH.
Okay - just another discrepancy in ingredient measurement here… but why do you count out the fillers and preservatives in mg/mL and when you get to the acid balancing part of the equation - you switch to percentages? Are we making a life-saving hormone here or a soufflé`?APIDRA, made by Sanofi-Aventis (NYSE: SNY) is a sterile, aqueous, clear, and colorless solution. Each milliliter of APIDRA (insulin glulisine [rDNA origin] injection) contains 100 IU (3.49 mg) insulin glulisine, 3.15 mg m-Cresol, 6 mg tromethamine, 5 mg sodium chloride, 0.01 mg polysorbate 20, and water for injection. APIDRA has a pH of approximately 7.3. The pH is adjusted by addition of aqueous solutions of hydrochloric acid and/or sodium hydroxide.
Of all the insulins I've used throughout my life - APIDRA was the ONE that broke the camel's back. Could it be the overabundance of meta cresol? Or perhaps does the dubious distinction belong in the Daltons of another foreign matter? You tell me.
Side effects of tromethamine include: renal failure. STOP. What's the point of insulin that comes a la carte` complications you are trying to avoid? Okay GO. Hyperkalemia - which is high potassium levels that could lead to heart failure. Still loving short-acting insulin analogues? "Electrolyte disturbances" -- just a nice way of saying chronic deydration, and hypoglycemia.
Just for kicks, we should all have a gander at the HAZMAT on m-cresol. Are the risks of such preservatives worth the benefits?
Potential Acute Health Effects of Meta Cresol: Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous incase of skin contact (corrosive, permeator), of eye contact (corrosive). Slightly hazardous in case of skin contact (sensitizer). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects of Meta Cresol:
The substance may be toxic to kidneys, lungs, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.
Chronic Effects on Humans of Meta Cresol: CARCINOGENIC EFFECTS: Classified POSSIBLE by IRIS. May cause damage to the following organs: kidneys, lungs, liver, skin, central nervous system (CNS).
So, in effect, the fast-acting insulin analogues chronically damage the Central Nervous System (CNS). It's NO WONDER long-term diabetes impairs the peripheral nervous system (PNS)! The CNS and the PNS work hand-in-hand (no pun intended). The central nervous system (CNS) represents the largest part of the nervous system, including the brain and the spinal cord. Together with the peripheral nervous system, it has a fundamental role in the control of behavior.
To summarize this blog in one question, I must ask: if you had a choice of a carcinogenic insulin with overabundant m-Cresol (for speed) or natural insulin (for safety)….isn't the choice obvious? Too bad the choice is no longer available.
- Wikipedia defines insulin analogues
- Preservatives in insulin and insulin analogues
- Side effects of tromethamine
- Tromethamine causes Hyperkalemia
- HAZMAT information on m-Cresol
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Categories: Consumer Safety,insulin,Big Pharma,toxins,DRUGS
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SO is the PRIME OBJECTIVE to reduce the INSULIN dose AND maximize the potential for Beta-Cell insulin & C-peptide ?
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CAREFULLY ALTER your DIETARY DIABETES PROTOCOL "DDP" to HELP MINIMIZE your INSULIN REQUIREMENT (?) in order to consciously help MAXIMIZE your Beta-Cell Insulin "BCI" production in response to Transient Supernormal Glycemia "TSG" which stimulates both BCI production and Beta-Cell C-peptide "BCC" production (?) ... and measure your YEARLY or QUARTERLY results ... with regular "STIMULATED C-PEPTIDE test" (?) ...
NB '...it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free ...'
1925 Fred Banting {www.tinyurl.com/2xrb8n & www.tinyurl.com/24eqyo} '...Regardless of the severity of the 'T1A diabetes', it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free. Since this is possible, it is to be strongly advocated, because we have abundant evidence for the belief that there is regeneration of the islet cells of the pancreas when the strain thrown upon them by a high blood sugar is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin...'
1978 Torsten Deckert {www.tinyurl.com/2krkv3} ~ MINIMIZING Non-Human INSULIN dosage = MAXIMIZES natural BCI & BCC-peptide SECRETION ~ '...T1 Diabetics (for approx 31 years) with a low daily insulin requirement (less than 0.50 units/kg body weight) still have Beta-Cells secreting Insulin & C-peptide ... in 24% of the Patients. Severe retinopathy was lower in the Secretors than in the non-Secretor group...'.
1987 Juan Grunwald {www.tinyurl.com/2d48d5} ~ conventional lowering of blood glucose, physiologically too fast, BENEATH kidney threshold CAUSES retinopathy.
2007 George King {www.tinyurl.com/2nr6b6} ~ insulin dose > retinopathy > Table 1.
2007 Halle Berry VIDEO {www.NicholasDynesGracey.blogspot.cOM/2008/03/how-may-sustainable-brain-glucose_07.html}
2008 George Eisenbarth {www.tinyurl.com/388dcb} ~ less insulin dose > less auto-immunity > more C-peptide ?
2008 "...when the natural 'down-regulation' adaptations {www.tinyurl.com/2po68s} thrown upon them by dehydration {www.tinyurl.com/ypozqv} and Relative HYPOglycemia Distress 'RHOD' {www.tinyurl.com/2uxb99} is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin; [aka 'CURED']?..."
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.11.MAR.2008 @ 19:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cO
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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So here are my questions: Is Novolog better because it has less meta cresol?
Is lessening the TDD the goal? (besides the goal of real insulin)
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Hey Michelle -- of all 3 short acting insulin analogues...it appears that Novolog contains the least amount of m-Cresol. I still, to this day, believe that APIDRA is the most **toxic**.
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Right on Allie! I have never been able to get a straight answer regarding preservatives in insulin from any of the so-called "experts". It seems that no one wants to touch the topic with a 10 foot pole. I guess we die either way, right?
I think the biggest problem is that we T1's have been brainwashed to think that we can live a "normal" life, which is just not true. We want to work shift-work. We want demanding careers. We want fast acting insulin so we can eat dinner like everyone else, we want to be able to eat cake and cover it with NovoRapid after the fact...
The fact is, we make no (or little) insulin. We have to inject insulin. Subcutaneously injected insulin does not work like insulin coming from the portal vein from within the body. It has to be absorbed through the skin, which takes time. Remember the old rule...wait 30 minutes after your injection to eat?
As such, if diabetics want to control their blood glucose without analogues, they must go back to the "old-fashioned" way of timed precise eating and simple carb restriction. I believe Bernstein supports this.
For many, they would rather try to "live a normal" life. But with T1 diabetes, you just can't.
Now, analogue benefits may outweigh the risk in those prone to severe hypoglycemia, for example. But I also think that this whole myth, that "diabetes is controllable" (T1 is usually not) or that T1 diabetics can lead a normal life is part of the problem. Analogues are not the holy grail of T1 diabetes advancement, they are an illusion of improvement.
We live in a "here and now" society, where everyone wants things fast. Unfortunately, faster insulin is not what one would have hoped.
Allie, did you compare m-cresol levels in analogues to those of animal insulin? What is the difference? THAT I am dying to know.
I still cannot believe that there is no way to access c-peptide on the market...it always comes back to that. Why even bother to take it out, when it's less work to keep it in?
Nick, you are a biochemist...assuming "natural" insulin still needs some kind of preservative, what do you suggest as a non/less-toxic alternative?
I am thinking that insulin would not last for more than a few hours on its own...?
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P.S. I use NovoRapid, and find that it suits me best. I have less reactions at my sites. I have heard similar stories from others. Coincidence? I don't know...
Treatment of the world's diabetics is the world's largest and longest running variable experiment...
(Please substitute "here" for "hear" in my above post...silly me).
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Hey Sarah,
I think that m-Cresol has been used for a long, long time – even in the days of animal insulins. The package for my pork NPH and my pork Regular (Neutral) it says it contains 0.145% – 0.175 % in each 10 mL vial.
I still feel safer on the animal insulins with a fraction of a percent per 10 mL vial than I do looking at contents in insulin analogues (in some cases) equivalent to the amount of insulin analogue.
Sadly the truth of the matter is we’re stuck between a rock a hard place making these decisions. I really don’t bother asking the tough questions any longer when I visit my doctors. The more I realize they DON’T KNOW – the more I realize they’re well trained by BIG PHARMA.
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.......All these preservatives that are now in rDNA Insulin and the potential for harm that can be generated, reminds me of what is and used in Vaccinations that your child is forced(depending where you live and how good of an attorney you have) to take.
As we all now are aware, the recent Supreme Court decision that awarded damages to a Neurologist and Wife(who is an Attorney) based on the horrible result of their daughter being diagnosed with Autism, which resulted from the Mercury that was contained in the Vaccine. Mercury is no longer added to Vaccines, but Aluminum can still be found in some. These metals are toxic.........and sometimes "a little" is enough to create " a lot" of damage.
I now want an Insulin whereby, I no longer feel as if I have T1DM.
Is that too much to ask for?
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Hey Barry,
Not too much to ask at all! In fact, I think if we were permitted to have equivocal glucose balance with a natural insulin – we all might have more control of our feelings c/o more glucose uptake to the brain and retinas and no t "force feeding" the cells in our trunk and peripheral limbs. The brain needs "food" too! Goodness gracious – we ALL might have nutrition available to our brain, to trigger neurotransmitter for FEELING GOOD, FEELING FED, FEELING HUNGRY, FEELING HAPPY, FEELING… (insert emotion here). Yes, genetically engineered and modified insulin analogues are bad news. The studies have never proved superiority, yet the BIG PHARMA GUN keeps shooting these “silver bullets”. DUCK!!!
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The preservatives are necessitated by the manufacturers because they do not produce insulin daily, but in massive batches which must be saved and distributed around the world, the bigger question is why has the FDA approved these toxic additives if they are supposed to protect the health and well-being of patients?!
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Sadly, as long as "the disease" and "the (non-compliant) patient" can be used to shoulder the blame for poor outcome, insulin manufacturing/marketing will continue along the current path. Doctors, by refusing to listen to patients and advocate for better tools (better insulins, more accurate meters, CURE research) certainly cannot be seen as part of the solution, ergo, they are part of the problem. Until 'someone' wakes up, though, we can depend on our Fatal Drug Administration to protect us.
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Better DDP = Less INSULIN = Less HYPOglycemia ?
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GlucoNeoGenesis Cures HYPOglycemia ...HOW ?
GlucoNeoGenesis is the generation of glucose from non-sugar carbon substrates like pyruvate, lactate, glycerol, and glucogenic amino acids.
The vast majority of GlucoNeoGenesis takes place in the liver and, to a smaller extent, in the cortex of kidneys. This process occurs during periods of INTERMITTENT... fasting, starvation, or intense exercise and is highly endergonic.
GlucoNeoGenesis is often associated with ketosis.
video >
www.NicholasDynesGracey.blogspot.cOM/2008/03/gluconeogenesis-cures-hypoglycemia-how.html
< video
Hi AnyOne, also re HYPOglycemia-Distress ... WHAT DO YOU DO or WHAT SHOULD YOU DO or WHAT DO YOU SUGGEST FOR every day 'FITTENING' the HUMAN BODY'S CAPACITY for NATURAL GlucoNeoGenesis?
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.12.MAR.2008 @ 12:23hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
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"The Gracey HYPO=thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2hht4z
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.Intermittent-Fasting.cOM
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/299t3f
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is NOT a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Food for thought:
Before the discovery of insulin, Type 1 diabetics were not long-lived. Either they succumbed to hyperglycemia, or died a slow death by starvation. Then Banting discovered insulin, and diabetic lives were changed forever. They lived . . . they lived longer . . . and coincidentally, now that they did live longer, they exhibited a number of ‘complications.’
These complications, ranging from amputation and kidney disease, to retinopathy and blindness were attributed first, to the nature of the disease, and secondly to the diabetic patient who, by his inability to achieve artificial goals delineated by healthcare professionals and scientific researchers, became his own worst enemy. This reasoning, at first blush, seems a reasonable interpretation of observable facts.
But another theory, which interestingly has remained beneath the radar, is that the very substances used to mass produce and deliver this life saving medicine were causative in the display of emerging complications.
Reading MSDS and Hazmat information is a provocative endeavor. When the known (and unknown) properties of the materials used to ‘preserve’ insulin (and new analogs that are the only available alternatives for U.S. consumers) indicate they impact the very systems/organs that are apparently ‘weak’ within diabetic biologic specimens, red flags should have appeared long ago within the community of intellectual questioners. Diabetes causes kidney disease? Diabetics who fail to maintain normal bG numbers are responsible for kidney disease/failure? [Substitute any other complication associated with diabetes for ‘kidney disease.’]
M-cresol has been shown to cause kidney damage at levels substantially smaller than what accumulates within an insulin-dependent diabetic over time. Why, then, is diabetes itself, or the non-compliant patient identified as the complications-culprit? Couldn’t the culprit just as easily be the M-cresol . . . or the phenol . . . or an unstudied combination . . . that is regularly injected into the patient’s body, and accumulates over time? Inquiring minds want to know. Why are the ONLY variables (1) the disease or (2) the patient? How does ‘insulin’ escape inclusion as another variable worthy of research? Apparently, once insulin (or an insulin-like product) is shown to (1) lower blood sugar and (2) not immediately kill the consumer, it is given a ‘pass’ when complications and their causes are examined. Why?
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VERY RARE ...
4% = 4/100;
0.4% = 4/1000;
0.04% = 4/10,000;
0.004% = 4/100,000;
4/100,000 = 1/25,000 ...
Massachusetts General Hospital admitted 47,899 patients over the period 1824–1898, of whom 172 (0.4%) were diagnosed with diabetes ...
The reported death rate from diabetes for children under 15 years of age was 1.3/100,000/year in the U.S. in 1890, as compared with 3.1/100,000/year in 1920 ...
Childhood type 1 diabetes was RARE but well recognized before the introduction of insulin. Low incidence and prevalence rates were recorded in several countries over the period 1920–1950, and one carefully performed study showed NO CHANGE in childhood incidence over the period 1925–1955.
An almost simultaneous UPTURN was documented in several countries around the mid-century. The overall pattern since then is one of linear increase, with evidence of a plateau in some high-incidence populations and of a catch-up phenomenon in some low-incidence areas. Steep rises in the age-group under 5 years have been recorded recently ...
www.tinyurl.com/34rq5m
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.12.MAR.2008 @ 21:14hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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HOW much have You got in your 'BOTTLE of COURAGE' to change your understanding ...To Be or not To Be GlucoNeoGenic FIT ...HOW ?
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video >
www.NicholasDynesGracey.blogspot.cOM/2008/03/to-be-or-not-to-be-gluconeogenic-fit.html
< video
The GlucoNeoGenic INHIBITING behavior illustrated above TREATS ... in a sometimes SUSTAINABLE, sometimes non-SUSTAINABLE way ... HYPOglycemia and/or treats, in a sometimes SUSTAINABLE, sometimes non-SUSTAINABLE way ... Relative-HYPOglycemia-Distress aka "RHOD" (?)
What GlucoNeoGenic behavior CURES ... in a substantially SUSTAINABLE way ... HYPOglycemia and/or cures in a substantially SUSTAINABLE way ... Relative-HYPOglycemia-Distress aka "RHOD" (?) and thereby avoids and/or PREVENTS the 'HYPOglycemia-STATES' ...WHY ?
BECAUSE an example of a 'HYPOglycemia-STATE' is a form of 'pre-diabetes' so barely distinguishable from 'pre-Type 1A' diabetes that One could reasonably suppose that the 'distress' referred to, way back in 1994/95, by Francine Kaufman as associated with CAUSING diabetes 'during an earthquake' ... may well amount to Relative-HYPOglycemia-Distress being the main avoidable CAUSE of T1A diabetes ...
EG ... "Autoimmune HYPOglycemia" aka pre-T1A diabetes ?
...Associated with the development of circulating anti-insulin antibodies as per T1A diabetes.
The development of anti-insulin antibodies has been reported in over 200 patients most of whom had medical issues with a gland, associated with DISTRESS adaption, called the "thyroid gland".
...The autoimmune HYPOglycemia is associated with eating and/or 'eating too OFTEN' and occurs 3-4 hours after meals following an initial post-prandial HYPERglycemic phase that is due to the antibodies interfering with the exit of insulin from the plasma to reach its target tissues. Later, after most of the meal is absorbed, inappropriate high levels of insulin dissociate from this antibody-bound compartment, resulting in HYPOglycemia. Insulin levels in excess of 1000 pmol/L are observed at time of HYPOglycemia, and these persons have high titers of insulin auto-antibodies aka pre-T1A diabetes (?) ... {so may this be an associated DISTRESS that leads to T1A diabetic 'HYPERglycemic compensation' (?)}.
Endocrinol Metab Clin North Am. 1999 Sep; 28(3): 603-18, vii.
Redmon JB, Nuttall FQ.
> 0999 www.tinyurl.cOM/3cr4ds {Redmo001@maroon.tc.umn.edu ~ Autoimmune HYPOglycemia}
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
Hi AnyOne, also re HYPOglycemia-Distress ... WHAT DO YOU DO or WHAT SHOULD YOU DO or WHAT DO YOU SUGGEST FOR every day 'GlucoNeoGenic FITTENING' the HUMAN BODY'S CAPACITY for NATURAL GlucoNeoGenesis?
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.13.MAR.2008 @ 11:27hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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http://ca.news.yahoo.com/s/afp/080313/health/health_children_diabetes
Vitamin D decreases risk of T1 by 29%....
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More concrete evidence on the *Regeneration of beta cells* and the importance of *C-peptide* in the prevention/delay/treatment of Complications that are a part of the Disease called T1DM:
β-cell regeneration to treat Type 1 diabetes mellitus
Authors: Barra Couri, Carlos Eduardo1; Foss-Freitas, Maria Cristina; Foss, Milton César; Voltarelli, Júlio César
Source: Expert Review of Endocrinology and Metabolism, Volume 3, Number 1, January 2008 , pp. 51-60(10)
Publisher: Future Drugs
Abstract:
"Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of the insulin-producing pancreatic β-cells. The autoimmune response begins years before the presentation of hyperglycemic symptoms. At the time of clinical diagnosis, less than 30% of β-cell mass still remains. The conventional therapeutic option to T1DM is daily insulin injections, which is shown to promote tight glucose control and reduce the majority of chronic diabetic complications. Subgroup analysis of the Diabetes Control and Complication Trial showed another important aspect related to long-term complications of diabetes, that is, patients with initially higher serum levels of C-peptide with sustained levels over the subsequent years suffered less microvascular complications and less hypoglycemic events than those patients with low or undetected C-peptide levels. In face of this, β-cell preservation is another important target in the management of T1DM and its related complications. Along the years, many efforts toward the identification of precursors of β-cells have been made, not only with the aim of understanding the physiology of β-cell preservation, but also as a potential source of β-cell replacement. In this review, we summarize the most important studies related to probable precursor cells implied in the process of regeneration, and the results of various immunomodulatory regimens aiming at blocking autoimmunity against pancreatic β-cells and at promoting β-cell preservation. Finally, we comment on the future perspective related to stem cell therapy in T1DM."
Affiliations: 1: Division of Endocrinology, Department of Clinical Medicine, School of Medicine of Ribeirão Preto. University of São Paulo, CEP 14051-140, Ribeirão Preto, Brazil
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Hi BetterCell,
Thanks for the heads up on the paper. I wanted to comment on its first line, just to keep the point alive and present. They stated: "Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of the insulin-producing pancreatic β-cells." This thinking is incorrect. While it is still the predominant thinking as to the cause of T1, current thought is that T1 starts as an inflammation problem, which progresses to an autoimmune response as a result of the inflammation. The culprit is environmental toxins which create the inflammatory response, not the patient's body turning on itself. It's a big difference. I hope eventually this penetrates the brains of researchers and they stop perpetuating this "blame the patient" myth.
Kelly
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Hi Kelly.......
I agree that there are many environmental Toxins that create havoc on the Body as a whole. However, where there exists a relative healthy/functional Immune System, many if not all of these Toxins can be eliminated.
There is a price to pay, which is more "wear & tear" upon the Body.
As far as Inflammation is concerned, this argument remains me of the "chicken & egg debate" as to which came first.
What I do know, is that Inflammation always accompanies the cellular destruction of any Body part. It is a way for the Body to try and create Homeostasis to a failing system. If Inflammation remains too long in any given area of the Body, then problems can arise. But this is a process where the Body does try to repair itself after any type of injury or insult.
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T0, T1, T2, T3 & T4 DIABETICS with less Relative-HYPOglycemia-Distress & less bottled 'Vitamin Diabetes' ... SUSTAIN more C-peptide and BETTER micro-vascular health ?...
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> 1006 www.tinyurl.cOM/yu4695 {JCVoltar@fmrp.usp.br ~ J.C. Voltarelli @ Universidade de São Paulo, Ribeirão Preto, SP, Brasil ... '...Secondary PREVENTION of T1 diabetes: reducing autoimmune 'Beta-Cell down-regulation' and promoting Beta-Cell Insulin "BCI" production & Beta-Cell C-peptide "BCC" production ?...'}
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> 1207 www.tinyurl.cOM/ys7vkw {Matthias@liai.org ~ Matthias von Herrath @ La Jolla Institute for Allergy and Immunology, California 92037, USA ... '...T1 diabetes is a relapsing/remitting/REVERSIBLE disease ?...'}
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> 0108 www.tinyurl.cOM/2thsjo {JCVoltar@fmrp.usp.br ~ J.C. Voltarelli @ Universidade de São Paulo, Ribeirão Preto, SP, Brasil ... '...T1 diabetes is associated with the autoimmune 'reduction' of the insulin-producing pancreatic Beta-Cells. This autoimmune 'Beta-Cell DOWN-REGULATION' may begin days, weeks, months or even years BEFORE the presentation of HYPERglycemic symptoms. At the time of clinical diagnosis, 'often' less than 30% of Beta-Cell mass still remains. The conventional therapeutic option to T1D is daily insulin injections ... Diabetics with less HYPOglycemic events sustained higher serum levels of C-peptide and suffered less microvascular complications over the subsequent years ... In face of this, preservation/up-regulation [www.tinyurl.com/2j5hmm] of Beta-Cell insulin production & Beta-Cell C-peptide production is an important target in the management of T1D and its related complications ?...'}
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Diabetes is NOT a disease ... www.tinyurl.cOM/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.cOM/36qxn3
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> 0192 www.tinyurl.cOM/2vp36k {Robert.Cohen@uc.edu @ University of Cincinnati Medical Center, Ohio, USA ... '...HYPOglycemia with HYPERinsulinemia ... following CALCITRIOL [www.tinyurl.cOM/2hpzxp] = VITAMIN 'D' [a steroid hormone precursor] which is associated with inducing HYPOglycemia [and associated down-regulation of insulin gene expression (www.tinyurl.com/2cgavg)] and CALCITRIOL aka 'Vitamin Diabetes' may induce Relative-HYPOglycemia-Distress (RHOD) by masking protective HYPERglycemia and may also lead to reductions in diagnosis of T1D and an associated increased incidence of Neuro-Psychiatric-Illness [www.Relative-HYPOglycemia.cOM]...'}
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Every Day Better In Every Way ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/03/every-day-better-in-every-way-how2.html
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.14.MAR.2008 @ 09:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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I've long wondered if the insulin itself could be the cause of what seems like a random crap shoot of who gets complications and when, except for retinopathy, which is pretty much a guarantee once you hit 20 years with D.
This just makes me sick (literally and figuratively), because what alternative do we have? If I go low, it's my fault (not that the bottle of insulin I have might have a different concentration than the one previous). If I go high, it's my fault. If I get a complication, it's due to years and years of ignorance and uncompliance on my part. The medication is infallible, of course.
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"Simple thinking" Amber brought on by the Medical Profession that seeks to blame the patient rather than the Disease or/and medication.
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Hey Amber - you hit it DEAD ON! The design of marketing to patients is "You need us. Thank your lucky Stars for Papa Big Pharma -- the answer to your prayers with the Science Fiction serum we call insulin analogues"
However the marketing to doctors sounds more like "this is the best stuff EVER!! You Trust us, don't you? We've had great results with former insulins. This is even better!"
Doctor then says to his/her their endearing Pharma Rep, "so why didn't you stick with the tried-and-true NPH and Regular formulas? In the 70s and 80s I had most of my patients on an insulin program that worked just fine for them. Why must you keep changing your product lineup?"
Pharma Rep replies, "Well, we know our scientific manipulation of the TRUE forms of INSULIN will cause complications. Plus, now we can patent our formulas and hold exclusivity in the market. In order to dodge the bullet of BLAME for complications deriving from our patented formulas --- and deflect the pain unto the 'noncompliant patients' -- we have to keep making 'new and improved' formulas/"
Doctor replies, "Okie dokie. Sounds good.. Thanks for the honest answer. Now about lunch for the office next week -- my stuff said Chinese sounds good..."
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I can tell you I had no overt signs of retinopathy after 30 years. I switched to Lantus (because Lilly discontinued my Lente insulin) and less than a year later the retinopathy started in earnest. Coincidence?
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Lara,
First, I am not a doctor so I cannot tell you to get off of this type of insulin. Personally, if it was me I would switch to Regular and NPH, take plenty of flavonoids (such as quercetin and bilberry extract). Lara, hang in there. I hope this helps!
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Lara (excuse the sarcasm)--pick one:
(1) Your tale is purely anecdotal;
(2) There is no scientific literature that indicates insulin causes retinopathy;
(3) There is no scientific evidence that switching insulins causes retinopathy;
(4) There is no evidence in the collection of adverse events reports by the FDA that insulin or switching insulin causes retinopathy (yet);
(5) Your opthalmologist failed to 'discover' the condition earlier; it may have begun long before you switched insulins;
(6) It's just the nature of diabetes; some individuals have complications, some don't. Get over it . . . live with it . . . things could be worse;
(7) You weren't a good diabetic; you brought this on yourself by your own non-compliance;
(8) Aren't you grateful that we now have interventions such as vitrectomy and laser photocoagulation to treat retinopathy?
(9) Purely coincidental. Just because "B" occurred after "A" doesn't mean that "A" CAUSED "B".
BTW,I AM sorry you're experiencing this nasty complication. Hopefully, your medical professional has caught it early, and treatment will delay further progression. The sarcasm was NOT directed at you, but rather at how most 'anecdotal' revelations are handled by our healthcare 'system.' The retinopathy cannot be 'talked away' . . . but any anecdotal observation or theoretical correlation by the patient is trivialized or negated by those with vested interests in treatments and/or drugs.
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Melody, we must be using the same Doctor and other Healthcare Providers. I have also heard the same statements as you so correctly posted.
But don't worry, the Cure is "just around the corner."
Which corner? I have been looking for that *corner* since I was six.
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Hey BetterCell,
I was waiting on that same corner in 1979, when I was told the cure is just around the corner. I guess you could say, I got a little impatient so I took a detour and decided to follow another path. The path has only gotten better each year!! I am so excited for the future...and, no my excitement has nothing to do with a cure around the corner. You have such a great sense of humor. I still cannot stop laughing....since I can totally relate to your post. Have a great weekend!
Julie
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Now they(Healthcare People) say that, the "Cure for Type 1 Diabetes is on the Horizon."
I guess that it(Cure) was moved from "just around the Corner" to on the Horizon.
I should have been told that the location was changed instead of spending so much time looking around Corners!!
Invest in Binoculars........
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BetterCell,
Now, I am really LOL! Are these some kind of special binoculars? Where did you purchase yours?
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Hi Julie......
The ADA is giving them out wjen a paid subscription to their Walkathons has been sent (People w/both Diseases who are told to walk for a few hours and giving the ADA money in order to do that). Both Diseases, I mean T1DM and the other, IRD(Insulin Resistant Disease).
Of course, when you receive your Binoculars you will find that the lens on either side is clouded over, which makes seeing the Horizon difficult if not impossible.
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BetterCell--
Guess the ADA changed designs. My "binoculars" have rose-colored lenses . . . and when you look through them, everything is beautiful.
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Hi BetterCell,
I am going to pass on those binoculars. LOL! However, when I am in New York, I will stop by and see the best chef...I think his name is Barry.
Take care, Julie
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Whether you've viewed this video before, or not, it addresses the discussion quite nicely. Titled "Skidmarks Disease in the Town of Allopath" . . . is probably speaks to an even broader audience when you take the time to 'digest' it.
http://www.youtube.com/watch?v=R4NEQzZlSDE
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Great video Melody,it explains it all.
What makes it worse is that organizations that are *suppose* to represent our interests such as JDRF and ADA are themselves part of the problem.
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Melody,
Thanks so much for sharing this video! It is so true....follow the money and you will have the answers. A cure for diabetes, would leave so many without jobs.
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Allie, great post.
Your timing and topic is amazing. I was just going to post this little research exercise I did on insulin preservatives in response to Brent’s post to an earlier blog you did. But, I’ll post it here instead.
In the way of background, previously I had done an extensive look at the research out there on various insulin types (posted at www.thediabetesblog.com), but I felt a surge of panic when I read Brent’s earlier comment. It sparked concern because I realized I had never looked at the quantity or toxicity of the preservatives in various insulins or incorporated that element into my decision of which insulin(s) to switch to when my hoarded stock of Ultralente was gone.
So – here’s what I learned. First, you’ll see a list of the preservatives in each of the major types of insulin used today along with a link to the source of the info. I haven’t covered them all. (For those I didn’t cover, the preservative list is generally shown in the package insert which you can generally find online by Googling, for example: Detemir “package insert”, with the quotes as shown.) Second, you’ll see a section called “So What Does This Mean?”
Detemir (Levemir):
LEVEMIR is a clear, colorless, aqueous, neutral sterile solution. Each milliliter of LEVEMIR contains:
100 U (14.2 mg/mL) insulin detemir,
65.4 mcg zinc/mL,
2.06 mg m-cresol/mL,
30.0 mg mannitol/mL,
1.80 mg phenol/mL,
0.89 mg disodium phosphate dehydrate/mL,
1.17 mg sodium chloride/mL, and
water for injection.
Hydrochloric acid and/or sodium hydroxide may be added to adjust pH. LEVEMIR has a pH of approximately 7.4.
Source: Package insert: http://www.levemir-us.com/prescribing_information.pdf
Lantus (Glargine):
LANTUS consists of insulin glargine dissolved in a clear aqueous fluid. Each milliliter of LANTUS (insulin glargine injection) contains:
100 IU (3.6378 mg) insulin glargine,
30 mcg zinc/mL,
2.7 mg m-cresol/mL,
20 mg glycerol 85%/mL,
20 mcg polysorbate 20/mL,
and water for injection.
(Inactive ingredients for the 3 mL cartridge are 30 mcg zinc, 2.7 mg m-cresol, 20 mg glycerol 85%, and water for injection. Note by Kelly: this is likely listed per mL, not the whole vial.)
The pH is adjusted by addition of aqueous solutions of hydrochloric acid and sodium hydroxide. LANTUS has a pH of approximately 4.
Source: Package insert: http://products.sanofi-aventis.us/lantus/lantus.html
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(Continued)
Humulin N
Each 100 USP units (1 mL) of biosynthetic isophane insulin human (Humulin® N) contains:
10–40 mcg of zinc/mL,
0.15–0.25% dibasic sodium phosphate (1.5 – 2.5 mg/mL)
1.4–1.8% glycerin (14.0 – 18.0 mg/mL),
0.15–0.175% cresol (1.5 – 1.75 mg/mL),
0.05–0.07% phenol (0.5 – 0.7 mg/mL)
(Note by Kelly: I’m making an assumption here that the contents are given in units of “w/v” which is “weight percent”.)
Biosynthetic isophane insulin (Humulin® N) human suspension has a pH of 7.1–7.4. Biosynthetic isophane insulin human (Novolin® N) has a pH of 7–7.8 and contains unspecified amounts of zinc, dibasic sodium phosphate, glycerin, cresol, and phenol.
Source: http://www.medscape.com/druginfo/monograph?cid=med&drugid=5218&drugname=Humulin+R+Inj&monotype=monograph&print=1
Hypurin Porcine Isophane (aka Porcine NPH) (Wockhardt UK):
Protamine sulphate, unknown quantity
Zinc chloride, unknown quantity
0.145-0.175 percent (w/v) m-cresol (1.45-1.75 mg/mL)
0.06-0.07 percent (w/v) phenol (0.6-0.7 mg/mL)
Sodium phosphate, unknown quantity
Glycerol, unknown quantity
Water for injections
Source: package insert, Wockhardt UK website: http://emc.medicines.org.uk/emc/industry/default.asp?page=displaydoc.asp&documentid=9774
(Note by Kelly: “w/v” is “weight percent” which is defined as: a 1% solution has 1 g of solute dissolved in a final volume of 100 ml of solution. Sources for understanding this: http://en.wikipedia.org/wiki/Percentage_solution, pharmacist at www.getcanadiandrugs.com, Wockhardt UK. The pharmacist at getcanadiandrugs.com that I spoke with, by the way, was very helpful and actually called Wockhardt directly to confirm the answer. They responded that the phenol level was 6.5 mg/10 mL vial, the centerpoint of the range they give on the package.)
Hypurin Porcine Neutral (aka Porcine Regular) (Wockhardt UK):
0.145-0.175 percent (w/v) m-cresol (1.45-1.75 mg/mL)
0.06-0.07 percent (w/v) phenol (0.6-0.7 mg/mL)
Sodium phosphate, unknown quantity
Glycerol, unknown quantity
Water for injections
Source: package insert, Wockhardt UK website: http://emc.medicines.org.uk/emc/industry/default.asp?page=displaydoc.asp&documentid=9780
Humalog (Lispro)
Each milliliter of Humalog injection contains:
100 units insulin lispro,
16 mg glycerin,
1.88 mg dibasic sodium phosphate,
3.15 mg Metacresol,
zinc oxide content adjusted to provide 0.0197 mg zinc ion,
trace amounts of phenol, and
Water for Injection.
Insulin lispro has a pH of 7.0 to 7.8. Hydrochloric acid 10% and/or sodium hydroxide 10% may be added to adjust pH.
Source: package insert - http://pi.lilly.com/us/humalog-pen-pi.pdf
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(Continued)
Humulin Regular
Each 100 USP units of biosynthetic insulin human (regular) contains:
10–40 mcg of zinc (however, Novolin® R contains approximately 7 mcg/mL of zinc chloride).
Humulin® R also contains:
1.4–1.8% glycerin,
0.225–0.275% cresol (2.25 – 2.75 mg/mL) and has a pH of 7–7.8.
Novolin® R also contains:
16 mg/mL of glycerin,
3 mg/mL of metacresol and has a pH of 7.4.
Source: http://www.medscape.com/druginfo/monograph?cid=med&drugid=5218&drugname=Humulin+R+Inj&monotype=monograph&print=1
So What Does This Mean?
Phenol (aka carbolic acid)
Phenol is rapidly and almost completely absorbed by the body. It’s also rapidly excreted. It seems to concentrate more in highly perfused organs: liver, kidneys and lungs. It’s highly toxic and it will kill you in large doses, but it’s not a suspected or known carcinogen.
Taking the mid-points of the concentration ranges given by the manufacturers, the phenol concentration per mL in the vial and the amount injected of phenol per day, respectively, at 20 units/day basal and 10 units/day bolus is:
Detemir (Levemir), 1.80 mg/mL phenol, 0.36 mg/day
Lantus (Glargine): 0 mg/mL phenol, 0 mg/day
Humulin N, 0.6 mg/mL phenol, 0.12 mg/day
Hypurin Porcine Isophane (Porcine NPH): 0.65 mg/mL phenol, 0.13 mg/day
Hypurin Porcine Neutral (Porcine R): 0.65 mg/mL phenol, 0.065 mg/day
Humalog, “Trace” phenol, unknown mg/day
Humulin Regular, 0 mg/mL phenol, 0 mg/day
(example: Basal: 20 units/day x 1 mL/100 units x 1.8 mg/mL = 0.36 mg/day)
Bolus: 0 units/day x 1 mL/100 units x 0.65 mg/mL = 0.065 mg/day)
For toxicity research, while I’m not sure it’s valid to do this and have emailed the EPA to find out, I looked at the oral daily reference dose from the EPA’s IRIS database (http://www.epa.gov/iris/subst/0088.htm">http://www.epa.gov/iris/subst/0088.htm). (There isn’t an injected daily reference dose that I’m aware of.) The EPA’s website states: “The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime.”
The oral RfD for phenol was recommended with “medium to high confidence” at 3E-1 (or 0.3 mg/kg/day). (http://www.epa.gov/iris/subst/0088.htm">http://www.epa.gov/iris/subst/0088.htm) At 160 lb, the “safe oral dose” recommended for no adverse lifetime effect is then 21.8 mg/day (160 lb x kg/2.2 lb x 0.3 mg/kg/day). So it seems, even the basal/bolus insulin combination with the highest concentration of phenol, Detemir/Porcine Neutral, delivers 50 times less phenol than the oral reference dose. Even at 100 units a day of straight Detemir, you’d still be getting 12 times less than the oral reference dose. This relieved my stress quite a bit on phenol exposure.
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Oops. My apologies on the Bolus calculation. It's supposed to read "10 units/day" not "0 units/day" - sorry for the typo.
Kelly
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(Continued)
M-Cresol (aka metacresol, 3-methylphenol)
Between the phenol and m-cresol, m-cresol concerned me more, and after looking at the numbers and the research, it still does. I have two case studies on drug intolerance reactions to insulin therapy caused by m-cresol and the oral reference dose is a lot smaller than it is for phenol. Taking the mid-points of the concentration ranges given by the manufacturers, the m-cresol concentration per mL in the vial and the amount injected of m-cresol per day, respectively, at 20 units/day basal and 10 units/day bolus is:
Detemir (Levemir), 2.06 mg/mL m-cresol, 0.41 mg/day
Lantus (Glargine): 2.7 mg/mL m-cresol, 0.54 mg/day
Humulin N, 1.625 mg/mL m-cresol, 0.325 mg/day
Hypurin Porcine Isophane (Porcine NPH): 1.6 mg/mL m-cresol, 0.32 mg/day
Hypurin Porcine Neutral (Porcine R): 0.65 mg/mL m-cresol, 0.65 mg/day
Humalog, 3.15 mg/mL m-cresol, 0.315 mg/day
Humulin Regular, 2.375 mg/mL m-cresol, 0.2375 mg/day
The oral RfD for m-cresol from the EPA’s IRIS database was recommended with “medium confidence” at 5E-2 (or 0.05 mg/kg/day). (http://www.epa.gov/ncea/iris/subst/0301.htm) So at 160 lb, the “safe oral dose” recommended for no adverse lifetime effect is 3.6 mg/day. This is a lot tighter than it is for phenol and if you’re taking higher insulin dosages, it could be an issue. At the 30 units/day total and using the basal/bolus combination with the highest m-cresol exposure, Lantus/Porcine Neutral would deliver 1.19 mg/day of m-cresol. While it’s still roughly 3 times less than the oral reference dose, 30 units is also less than what a lot of people take and exceeding the oral reference dose is definitely doable depending on the dose and combination of insulin types taken.
So, for me, the end result of my research exercise on phenol and m-cresol is that it renewed my motivation to reduce the amount of insulin I am taking as much as I can and it further reinforced my decision to switch to porcine (which by the way is working out very well for me, although I’ve only been on it for 3 days now.) While I wish neither phenol or m-cresol were in insulin as preservatives and still question why they can’t or don’t use something else, the research reduced my concerns regarding toxicity considerably, at least for phenol and m-cresol. I plan to take a look at the other preservatives, particularly zinc, later, but that was the energy I had for it for now.
As a cautionary request, please check my numbers and run your own calculations before making decisions.
Kelly
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Kelly, thanks for doing the research on the other insulins. very helpful.
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Hello again,
For those interested, the two papers I mention by the way, that I have on meta-cresol sensitivity are:
(1) Kim D, Baraniuk J. Delayed-type hypersensitivity reaction to the meta-cresol component of insulin. Annals of Allergy, Asthma & Immunology. 2007; 99: 194-195.
(2) Clerx V, Van Den Keybus C, Kochuyt A, Goossens A. Drug intolerance reaction to insulin therapy caused by metacresol. Contact Dermatitis. 2003; 48: 162-163.
Of note, this second paper states: "As almost all commercially available human insulins contain metacresol, only the few with other preservative agents (Monotard, Ultratard) can be used in diabetic patients with metacresol allergy. When Novo Nordisk became aware of the possibiltiy of such reactions, they produced a short-acting insulin containing methylparaben as a preservative instead. This metacresol-free insulin is not commercially available, but can be obtained from Novo Nordisk once allergy to metacresol has been demonstrated."
This is interesting to me in that Novo Nordisk recognized the problem exists and provided an alternative but removed both Ultratard and Monotard from the market for commercial reasons in 2005. Secondly, while you may be able to get a metacresol-free product still from them, they substitute methylparaben for the meta-cresol and the amount wasn't stated.
Methylparaben isn't listed in the EPA's IRIS database and there's pretty much zero information out there on its known toxicity so it's hard to say if it's a good switch or a worse one. The EPA knows methylparaben is an endocrine disrupter though. So gee - seems like a good idea for anyone with diabetes doesn't it? Anyone up for a little sprinkle of endocrine disrupter with your insulin?
Me neither.
Kelly
(P.S. If you haven't already, you might want to start watching your shampoo, soap, deodorant, laundry detergent, cosmetics, etc. labels before purchase. They pretty much all contain parabens unless you deliberately search for alternatives.)
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Wow Kelly! When I was diagnosed in July 1985 -- the insulin doctors started me on was the *first generation* Humulin NPH and Humulin Regular. I used to ride horses. I was diagnosed over the summer, so I couldn't go to riding camp in 1985. But when went back to the farm for lessons, in the fall -- ALL OF A SUDDEN I had asthma
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Hi Allie,
When I googled "Actrapid "package insert"" and "Insulatard "package insert"", both brought up files that show both types contain meta-cresol as well. The files I found were: http://www.emea.europa.eu/humandocs/PDFs/EPAR/actrapid/204302en6.pdf and http://www.emea.europa.eu/humandocs/PDFs/EPAR/insulatard/206002en6.pdf.
Unfortunately, neither of these files contains the quantity of the preservative, they only list that the insulins contain it.
From the 2 articles I have, neither flagged asthma as a intolerance reaction to meta-cresol, but I'd check out the EPA's IRIS database. There very well may be a link that's talked about there. The link for that site is in my earlier post.
Kelly
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TIME for Training your ALPHA cells ...HOW ?
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www.GLUCAGON.cOM
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www.NicholasDynesGracey.blogspot.cOM/2008/03/time-for-training-your-alpha-cells-how.html
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.16.MAR.2008 @ 22:15hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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WHO is responsible for the DOSE of WHAT is prescribed from within an INSULIN bottle (?) ... and ... Hippocratic Oath like RESPONSIBILITY lies with Every Licensed Physician to act as a FILTER between FREE ENTERPRISE and Patients' long term health ...HOW?
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The Hippocratic Oath says: "...To please no one will I prescribe a deadly drug nor give advice which may cause his death..."
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> 0107 www.aapsonline.org/ethics/oaths.htm [AAPSonline.org]
... 2006 www.tinyurl.com/2gtyp4 [Roy_Poses@Brown.EDU]
www.en.wikipedia.org/wiki/Euthanasia
> 0950 www.tinyurl.com/345uzh [TIME.com]
... 2007 www.tinyurl.com/3xv8y2 [lsn@lifesite.net]
> 0407 www.tinyurl.com/2dad25 [Kauffman@hslc.org]
... 2007 www.tinyurl.com/2jphjr [Rob.Butler@uhns.nhs.uk]
... 2007 www.tinyurl.com/2c3yj8 [Malcolm@llp.org.uk]
> 0107 www.tinyurl.com/2tt8ho [healthexpert]
> 0107 www.tinyurl.com/2jlt7v [funniinnit]
... 2007 www.tinyurl.com/yqmqnj [Kauffman@hslc.org]
... 2006 www.tinyurl.com/nx2bk [BBC.co.uk]
> 0103 www.thincs.org [Ravnskov@tele2.se]
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…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.17.MAR.2008 @ 23:34hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Don't forget the dangerous additive SODIUM CHLORIDE! That can kill!!! (It's also known as table salt, is used to make "normal saline", which is the concentration found normally in the body.) Have fun here at your conspiracy website..... Keep up the specious arguments; don't let facts or real science get in your way.
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Judith=Shill?
http://en.wikipedia.org/wiki/Shill
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Judith—
Show me the REAL science. Once industry encroached on academic/scientific autonomy, what you currently call REAL science would be more realistically labeled PSEUDO science. Can you show me the REAL science that indicates additives in insulin vials are (1) not accumulated within the human body with prolonged usage; (2) that additives are NOT harmful to humans; (3) that additives do not interact (harmfully or otherwise) with the pharmacopeia that now comprises diabetic treatment protocols.
Since you are such a fan of REAL science, I assume you know how to access REAL science data. Would you please put to rest a conspiratorial notion I’ve been unable to bury. For more than 2 decades, insulin-dependent diabetics have been told that human insulin is “just like the human body makes.” By what scientific standard has this statement been truthfully analyzed? I asked this question on another blogsite . . . and was told: “the description of the molecular make up of R insulin is in the prescribing information.” If the “real science” is that cute little 2-dimensional rendering of the insulin molecule contained in the package insert and the PDR . . . I would question REALITY.
Having submitted samples of various ‘insulins’ for analysis, the closest I could come to validating this statement was that the atomic weight of the samples were within a very narrow +/- range of standard. In other words, Humalog and Humalin weigh the same—but they certainly are NOT the same product. The “identical moality” of Humalog and Humalin does NOT address the spatial configuration (you know, those arcane little ‘real science’ issues like disulphide bridges, proper folding, etc.) When this basic “REAL science” issue cannot be adequately addressed because of the manner in which analytical technology trails discovery, how can we place any credence on the REAL science you currently hail as truth.
When rDNA human insulin was first marketed, it was “just like the human body makes.” As patent expiration approached, new analogs were better, and problematic issues of human insulin were disclosed. In other words, yesterday’s REAL science, seen through the lens of time, was actually PSEUDO science. “Fool me once, shame on you—fool me twice, shame on me.” Yet, you prefer to label anyone who does not eagerly embrace the latest offering of “REAL” science as a wingnut conspiracy theorist. I wonder why that is?
When (current) REAL science validates only industry beliefs, and shifts as economic issues change, there is basis for conspiratorial beliefs. When (current) REAL science is founded on faulty PREMISES, all truths that issue from such science are suspect, and until proven otherwise are as deserving of the label PSEUDO science as they are of REAL science. SHOW ME THE SCIENCE.
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I am very interested in your take on insulin preservatives. I am a Type I diabetic for the past 40 yrs. I have been on an insulin infusion pump and use Novolag. My concern is (a) insulin preservatives infused for the past 40 yrs. containing carcinogens and (b) the pump tubing manufactured out of PVC causes what carcinogens to leech into the insulin and in turn in your body. What scientific documentation and or studies exist on these two subjects. Please respond.
Thank you
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Lawrence--
Interesting. I have been a diabetic for 50 years, and also have concerns regarding the cumulative effects of other components in the vial of insulin. You might want to be concerned about what rDNA "pollution" is in the modern insulins.
BTW, my friend was one of the first to "pump" in our locale, using pH-adjusted regular insulin. He switched to Humalog in 1996. He has tried Novolog and Apidra. He is now more concerned about the effects of these newly-created synthetic hormones. How is it that you have been on a pump for 40 years?
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hi allie my daughter is presently in the laramie wyoming hospital because of diabulimia we didnt know until about a month ago about this disorder the hospital is trying to find a eating disorder clinic that will take her medicaid so far no luck they dont want to discharge her because she is so high risk this is probably her 9th go around with ketosis do you know of any places that deal with this disorder and will take her medicaid??? we are at a loss and my daughter erica is giving up hope thank you for your time valerie rodabaugh
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Dear Valerie,
I fear to say that *most* medical practitioners (including eating disorder clinics) do not understand what causes people with diabetes to *resist* using insulin. It is assumed that the insulin is just like human insulin, when in fact - it is NOTHING like a vertebrate insulin. The medical community labels the reaction (skipping insulin and losing weight) as a dubious plot for a person with diabetes to lose weight. They call it "diabulemia" so they can assign yet another malfunction in the patient-- rather than identify the cause in a problematic medicine = genetically modified insulin analogues.
I struggled with the condition labeled "diabulemia" for 15 years - from the age of 14 till I was 29. I was programmed to blame myself for inadequate and faulty tools in diabetes treatment. Guit is the sine qua non for Big Pharma. Without which they would have to own the consequences of the dangerous tools they patent, manufacture, and profit from (hand-over-fist).
If your daughter is like me - she is reacting to the side effects of using ineffective genetically-modified insulin analogues. If she's doing what I did - it's because the insulini analogues feel unnatural to her body...she would rather run high all the time, rather than take the analogue and suffer the unrewarding and erratic side effects: weight gain, swelling, confusion, erratic glucose swings and feeling like the world is moving in constant fast forward. It's unlikely and unfair that she has NEVER been offered a natural insulin like beef or pork. They are not made from e.Coli or yeast -- another reason her body may not do so well on insulin analogues. The absorption rates confuse the neurotransmitters in the brain for hunger and satiety. Furthermore, insulin analogues are not recognizable to vertebrates (mammals with a central nervous system) because the analogues are made by unicellular organisms (without central nervous systems = a brain).
I can offer 2 things for consideration: 1) see if you can get medicaid to cover animal insulin for your daughter. It is safer (more certainty in blood glucose control), just as effective, and less costly than any analogue on the market. 2) I don't know how old she is -- but if she'd be willing to try an organic, low-glycemic (reduced insulin needs), diet... she may find the combination of natural insulin + low insulin needs = metabolic stabilization (aka less likelihood of manipulating insulin dose) Two doctors who come to mind (who also have books) are Dr. Richard Bernstein - The Diabetes Solution and Dr. Joel Furhman - Eat to Live. Don't let the dramatic title fool you. His formula for eating reduces the body's need for insulin in diabetes treatment (Type 1 and Type 2). Dr. Bernstein's book is a gospel to many of us. I bought it a few years ago and have continued referring back to it, time and time again.
My struggle with overcoming (misnamed) "diabulemia" included: natural insulin (pork NPH and Regular) and low-glycemic eating. My body began to respond to insulin (the right kind of insulin) and my mind, body and (recently discovered) soul came together in a harmony I've never known. Life with diabetes is actually not as miserable as it had been under the ineffective regime of insulin analogues.
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Valerie and Allie,
Allie - since you also fairly recently switched to porcine insulin, I was wondering if you (or anyone else out there!) might have a take on this experience I'm having, which might also help Valerie in her journey. Here's the scoop.
I am just now into my second vial of porcine Isophane after switching from genetically engineered Ultralente. It's gone very well. This last week, I tried something new for me - shock - I tried eliminating yeast and processed sugar from my diet. I know it seems like that would be the number 1 thing for a "diabetic" to do, but I've never really forcused on either. In any event, I still eat natural forms of sugar (agave nectar, honey, etc.) but have made a focused effort to really cut out virtually all processed sugar (and other foods for that matter).
For about the last 6 months or so, I've been deliberately running my sugars higher - often in the 200's - not to lose weight, but to give my pancreas some breathing room to relearn how to work. My thinking has been that there's no way my pancreas can budge if I keep slamming it with exogenous insulin. Diabulemia? Whatever. Deliberately and consciously not using insulin when I would have otherwise - yes. Something my doctor would advise against - yes.
So here's the thing. When I took out yeast and processed sugar - shock - within 3 days, I also needed virtually no humalog to keep myself in the 100's within 2 hours of a meal. With that out, the only insulin I've been taking is the basal porcine Isophane. And interestingly, I've been really dizzy virtually all week. Strange - but, it sure seems like withdrawal symptoms to me (not that I've experienced that before). But - has anyone had this experience? Take out GE insulin and experience withdrawal symptoms?
There's no chance I'll find anything on this in the research so any thoughts out there would be appreciated. Obviously, I could be experiencing a bug of some sort, but the timing strikes me as pretty odd.
Kelly
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Allie.......I applaud you for wanting to help Valerie's daughter who is now in the hospital waiting for the Bureaucracy to "kick-in."
The problem is, that Medicaid will not cover Insulin(animal-derived/porcine) where it is gotten from another country.
So, unless I am mistaken she might only be
covered for the GM analogues..........and then the
problem is not solved.
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to prevent and cure diabetes and to improve the lives of all people affected by diabetes.
The above is the ADA “mission statement.” Why can’t THEY help Erica (and others like her, who fall through the cracks)? A little bit of ADA intervention/advocacy would “improve the lives of both Erica and her family”—certainly fits the mission criteria, doesn’t it? Where are true advocates? Ombudsmen? Valerie—have you contacted your Congressman and/or Senators? How about local and regional newspapers?
Sadly, while some diabetics have been afforded a pathway to import natural insulin for their own use, they are cannot resell, transfer, or altruistically share their imported product: these are the constraints that accompany personal importation. As far as I know, no doctors , hospitals or pharmacies stock the product.
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Hi Melody........
The ADA appears to be a top heavy bureaucratic organization that is only focused upon THEMSELVES and the other disease known as IRD(aka Type 2 Diabetes).
Oh, I forgot........they also like to organize long park walks in the Summer.
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hi its valerie how do you get the animal - derived insulin boy i thought there was just the kind we get from the dr i am pretty stupid i didnt know we had choices
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Hi Valerie,
Doctors don't tell you. They were all sold the same "bill of goods" from Big Pharma that they then sold to us when the GE insulins came out in the late 80s. I took GE insulin for 20 years before I figured it out. The easiest way I've found to get Porcine insulin is through Canada at www.getcanadiandrugs.com. It takes about 4 days once you order it and no prescription is required. Porcine Isophane is the longer acting; Porcine Neutral is the short acting. I'd make sure you call Medicaid and talk with someone first and learn exactly how to file a claim and who to send the claim to before buying though. They might not allow it, as BetterCell said, but it is definitely worth checking out and not assuming. It's expensive (about $131 a bottle) out of pocket before you get reimbursed. Shipping was about $15. You can import it directly from Wockhardt UK in Britain as well, but they have 5 hoops to jump through and they're big ones (importation permit, letter from doctor saying GE insulins won't work for you, prescription, letter from you, and lots of added expense in "administrative fees").
Kelly
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Kelly.....I just wanted to add that most if not all people who are on Medicaid are unable to afford the animal-derived Insulin or even have enough $$ for food and the necessary amount of Food Stamps provided to be able to eat properly.
Medicaid and Medicare Recipients represent Numbers and Debits to the Government(there are no Faces of the people in need)....nothing more. Thus, they would rather see more of a deficit rather than an increase related to these two agencies.
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BetterCell,
I'll add back - While it is certainly true that a lot of people who are on Medicaid truly need it and the picture you provide is accurate, it's not always the case. For example, in Washington at least, 42% of births are paid for by Medicaid. That's virtually half the female birthing population, and there's no way that the picture you present holds true for that many women here. For a good percentage - and certainly not the majority I would hope - it is a lifestyle choice. Medicaid provides the basics in health care needs; and, if you aren't in to following our culture's somewhat ridiculous notion of identifying yourself by your work and relying upon your employer for health care coverage, Medicaid can be a viable option to health care access, particularly if you're not too concerned about HMOs.
Kelly
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Bettercell,
Are you 100% certain of that? If someone has a legitimate allergy to GE insulin, which does happen, they have no option but to switch to an animal based insulin. If that's the case, Medicaid would HAVE to cover it. To get my animal insulin covered by my government insurance plan, my doctor wrote me a letter stating my diabetes wasn't adequately managed using GE insulin (to meet Wockhardt's requirement for importation). I think what might be needed is to find a doctor willing to write a prescription for the animal insulin and support her decision to switch. I've found 2 doctors willing to support me and my insurance is willing to cover it. I don't know about Medicaid's willingness to cover imported insulin, but while it's pretty safe to say they won't cover shipping, my guess would be that they will cover animal insulins, but that you'd have to do your homework to find out what hoops you have to jump through. Are you 100% sure?
Kelly
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Hi Kelly......Each state has its own rules regarding Medicaid coverage.
As a rule, Medicaid does "not like to jump through hoops."
Private Insurance plans are always more flexible than Government ones.............because you are paying for them rather than the state.
Valerie would( and should) have to find out by calling her local Medicaid office to see whether they would cover Insulin not locally available.
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BetterCell,
Thanks for the clairification.
Valerie, I'd also add that if your Medicaid office says "No, animal insulins aren't covered." I'd ask them to specifically show you where the rule is, in writing. If they can't produce it, I'd petition it to the head of the Medicaid office via hardcopy letter and CC it to the head of your Department of Health. I know it sounds like a lot, but it's amazing what a few letters to the right people can do to get people moving. (They don't like the attention if they know they're in the wrong, which they probably are in this case if they say "No.") Also, in general, what I've seen at the Medicaid/Department of Health level is that they tend to think people who are on Medicaid won't be willing to fight for their rights, so they can, sometimes unbelievably so, abuse people's rights just because they think they can. I'd seen a pretty amazing example of this in regard to birth costs, around 50% of which is covered by Medicaid in my state.
Kelly
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hey allie thanks i have left a message with erica's dr to look into the other insulin my number is 3073243558 iam there in the evenings wyoming time after 630 but if you could call erica that would be so awesome she is about to give up hope she has been in the hospital for almost 2 weeks and still no luck with anyone taking her insurance the hospital wont let her leave till they find someone to take it erica says why did i finally ask for help when no one can help me i dont think people understand her maybe if you could call her it might help for someone who has been there i would appreciate it she is so down she is at the ivanson memorial hospital in laramie wyoming 800-854-1115 on the behavorial floor 3 her name is erica sanchez god bless
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BetterCell--
You've got that right. I am so angry at the 'primary' advocate for "ALL" diabetics that I could scream . . . which I have done--in writing--to the ADA. I KNEW they were top-heavy in administrative expenses; but when I discovered that 26 cents out of every donated dollar goes to fund raising, the shade of red I was seeing deepened.
I am the proud recipient of untold numbers of their "every nickel count" fund-raising campaigns. I initially wrote them, and explained that if they had saved the nickel they sent me--together with their bulk postage fee--they would be 40 or 50-cents closer to finding a cure, preventing diabetes and helping all diabetics. Please, I implored, remove me from your mailing list. NOT! I now have 3 more solicitations, which I plan to take to my state's AG or Consumer Advocate to see what it will take to TURN THEM OFF. I even wrote a chastising message to the organization, with copy to the ADA Pres, asking that if they can't do the job they CLAIM to be doing, could they at least take me off their list. No answer.
I suppose those long summer walks have a bG-lowering effect; but do you really think the participants would work quite so diligently if they KNEW how very little of their money goes to cure/prevention research?
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It's the Sheeple following the Sheeple Melody.
Many people don't want to see what is going on or are unable because of all the hype.
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DAUGHTER, AUSTIN, 22, TYPE 1, BI POLAR, BLUMIC, HOSPITAL 48 TIMES IN 2 YEARS. SUGARS 12 - 1,200. A1C 14, USUALLY 300 -HI. THERE IS A EATING DISORDER CLINIC IN CHELSEA, AL "MAGNOLIA CREEK", TRIED TO GET HER TO GO, SHE'S NOT READY. SOME DAYS TOO SICK TO STAND UP. SOME DAYS FINE. BRIGHT, WITTY, ....VOLUNTEERS AT DIABETIC CAMPS AS A COUNSELOR, YET..........HELP
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Bobbie (and Valerie)--
How I wish medical professionals could see posts such as yours and recognize that "anecdotal" observations and reports represent REAL people living in the REAL world, who do NOT necessarily fit in the one-size-fits-all mold.
Wish I could offer help instead of merely sympathetic support.
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Hi,
I am a type 1, had it for 25 yrs.
Glad to see I am not the only one, although I feel that way at the doctor's office. I can no longer use any of the analogues because of the effects on my body (numerous). It took me a while to figure this out and finally get on a pump using Humulin R. This after 9 years of Humalog. Feeling so much better staying away from all the new insulins. Everything went down hill fast when started using Lantus/Humalog.
I wonder about all the newer insulins and if they are not tracked by the doc's properly. T1's are such a small percentage of the users of these insulins I wonder if the drug companies even care? Why else would U and UL be removed from the markets even though they are Human origin? We don't have much to draw on if they remove the backup insulins R and N.
Many T1's may read this and say:"I am doing fine with the analogues." I may have been one of them 5 years ago while on H and N. This stuff sneaks up on you fast if it happens, it may not.
I short, thanks for raising awareness about this issue!
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I'm Type 1 and have been for the last 36 years. I'm currently using Humalog because I'm on a pump and I was told that the pump only really works with either Humalog or Novalog. I used to be on Humulin R and NPH, which I was on for several years. I had nothing but trouble on them and had such a hard time controlling my blood sugar that I would go into a coma 2 to 3 times a week. Ever since they put me on the pump that has all stopped and, no more diabetic comas. I've already had complete kidney failure, which happened several months before I was even put on the Humalog. I also have Neuropathy and several other complications of the disease. Right now they're telling me that the only other way to deal with this is to get a kidney/pancreas transplant, which is still not a permanent fix since they both will probably fail eventually and I'd be right back the way I am now.
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Hey Marc,
I tried the NPH / R injection routine. When I was first diagnosed until the age of 19. I went on the pump at 19 and wore it till the age of 28. I took shots for a year and then a friend suggested I go back to the pump. Some of us prefer the pump and other prefer the daily injections. I prefer pumping – it’s the convenience factor for me.
Insofar as the kidney failure, and kidney/pancreatic resolve – I see where you are coming from. It’s not an “answer”. In fact I’m annoyed when doctors suggest such a “remedy”. I’m reminded that doctors do not know the daily mental torture that comes along with the trials of living with diabetes.
After all – they think controlling blood glucose with “insulin” is THE answer. It’s one thing to know what you’ve been taught by the industry. It’s another thing to think about the aftermath. I say we call for more thinkers and less “know it alls”.
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Maybe all the years these preserves have been in use (I dunno... since the early years that pharma manufactured insulin for mass use) its these toxins that are causing some of the complications and not the diabetes. And in light that the fast-acting insulin have more concentrations of m-cresol etc in them, and since these fast-acting have been introduced A1Cs have gone down to great numbers but complications have increased. If it was true, all these years pharma was slowly poisoning us all but masking it in the mystery and blame game that is diabetes.
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I simply cannot see how someone can go back to injections after being on a pump. When I was on shots, my control was terrible. I would go into low blood sugar comas at least a couple of times a week and some of them were extremely bad, so bad that the paramedics that showed up to revive me told me that they couldn't understand why I didn't die. From the first day that I started on the pump, all of that stopped. The doctor that's handling my pump told me that I'm doing way better than he ever expected I would. And the great thing about the pump, at least for me, is that I can go all day without eating which is a HUGE advantage for me. That was the one of the worst parts about being on shots is that if I didn't want to eat I had to rearrange my whole insulin schedule. Or if I took a shot and then decided that I just wasn't really hungry, I had no choice but to eat when I didn't want to. I was on 5 shots a day towards the end so, unless I absolutely have to, there's no way I'm going back to shots.
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Marc--
I think this is called 'different strokes for different folks' . . . and is EXACTLY the reason that we need MORE choices and FREEDOM of choice. I had the same experience with Beef Ultralente that you do with the pump. I took 'basal' injections, approximately 12 hours apart. If I chose to eat, and when I chose to eat, I could bolus with Regular injections--and injections are no more worrisome than a gnat bite. Great control, great A1c's, and freedom to eat or not, as I chose. But MY choice was removed--"just a business decision" based on (manufactured) unpopularity. Besides delivering very problematic insulin--FOR ME (I experienced my first hypoglycemia unawareness event), the pump impeded my activity. Bad infusion sets and priming wastage were secondary problems; the greatest was merely the feeling that I had an extra appendage.
Do you suppose pump users will feel the same sort of anger I do if/when "newer, patented, more expensive technology" pre-empts YOUR freedom of choice. What happens if inhaled or oral-delivery becomes the "latest, greatest and ONLY" method of delivery?
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I've also tried Lantus for awhile, once every 24 hours. Then I would take Humalog for food intake. One of the problems that I had was the fact that I've had diabetes for over 36 years now and I've been told that my body doesn't absorb the insulin the way it used to. I also have a lot of scar tissue under the skin where I give injections and these sometimes either prevent proper absorption or what would sometimes happen would be my taking an injection and then instead of using it, my body would sort of, 'hang onto it' for several hours. My blood sugar would be high so I would take another shot and then the first shot would finally kick in and I'd have a double dose in me. There were several times that this happened and even though I had just eaten a large meal, I would suddenly go low and pass out. Once I went on the pump, this all stopped and my sugars are running very close to normal most of the time. For me, if all the pump did was to stop the 'passing out' instances for me it would have been worth switching. But it did that and it also has my sugars running normal most of the time. So its like an added bonus I guess.
As far as 'things in my Humalog' that may be causing other problems, well, I don't worry about that because the stuff is working for me. As far as I know, all of the problems that I have, I'm sure that they've been caused by the diabetes. However, I do not dismiss the possibilities that the insulin MAY be causing some things that would not occur if I was not on insulin.
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For T-Mobile’s G1, there will be a bundle of tmobile g1 accessories online to select from; everything from Backup Batteries to Car Accessories, G1 Cases, Chargers, Cables, Headphones, Cradles, Bluetooth Accessories, and more. The list goes on and on, but basically the primary purposes of any g1 accessories are to add functionality, such as where you can use it and what you can use it with, make some features easier to use, and extend the use of the G1 Android phone at Fommy.com.
http://www.fommy.com/accessories.asp?make=T-Mobile&model=T-Mobile+G1&cat=Cases
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I would like to appreciate your efforts which you have made in writing this article.
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Thank you for this article, and for all the comments and experiences. My 10 year old daughter was just diagnosed with T1 Diabetes, so this is a whole new world. Our early research has lead us to successful reversals of this disease by adopting a fully raw food dietary program. We've been working with this as a family for the last several weeks, and the insulin needs have been dropping down. We have been able to stop using Lantus all together as long as she doesn't eat too many nuts. Have any of you tried this type of programs and have you found success? http://www.youtube.com/watch?v=jSuqCMld00w
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.
Hi Rama,
This is very great news.
Please study these comments on nuts and inflammation ...
*
http://alliesvoice.com/search.aspx?q=nuts&sc=tconcom&dt=a&al=
Inflammation [and most cooked food] is associated with Artifactual HYPOglycemia ...
*
http://www.jstage.jst.go.jp/article/endocrj/50/4/481/_pdf
And as You will find from reading some of my comments ...
*
http://alliesvoice.com/search.aspx?q=Gracey&sc=tconcom&dt=a&al=
... it is my firm belief that avoiding Relative-HYPOglycemia Distress is the key to progressively achieving the result that You seek [Every day Better in every way].
A Human body that is progressively protected from the challenges of acute & chronic Relative-HYPOglycemia Distress can be expected to progressively increase its capacity to produce its own HYPOglycemic chemicals, as required, including proinsulin [Every day Better in every way].
...Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.28.DEC.2008 @ 12:14hrs c/o www.LIFE2345.cOM
.
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Could you help me. The radical of one century is the conservative of the next. The radical invents the views. When he has worn them out the conservative adopts them.
I am from Herzegovina and too poorly know English, tell me right I wrote the following sentence: "Ca is your online source cheap flights, discount airline tickets, last minute airfares cheapest airfares."
Thank 8-) Berthold.
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to tell the truth, from what youve written Berthold, I couldn't understand anything!
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Very interesting site, beautiful design, thank.
I am from Benin and , too, and now am writing in English, tell me right I wrote the following sentence: "More non google seo how to online marketing resources for.Professional search engine optimization services, professional seo services for small business websites stacey from jezsta seo services made this good point."
Best regards
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We love you Allie for speaking the truth-
Its time to file a federal class action law-suit-
even though probably a longshot- still
we (as diabetics) have a shortened life span due to these pharma-criminals anyways-
please contact me to proceed-
God bless you!
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Colin--
Great idea . . . do you have the wherewithal to pursue this? It HAS been done at SUZAN KAWULOK, INDIVIDUALLY AND
AS REPRESENTATIVE TO THE CLASS;
VARIOUS UNNAMED JOHN DOES AND
VARIOUS UNNAMED JANE DOES INDIV
AND ON BEHALF OF THE CLASS,
Plaintiffs,
vs. NO. CIV 00 0459 BB / LFG
ELI LILLY AND COMPANY; and NOVO NORDISK,
Defendants.
FIRST AMENDED COMPLAINT FOR NEGLIGENCE,
PRODUCTS LIABILITY AND PUNITIVE DAMAGES.
There were undetermined shenanigans in this case. First Lilly lawyers failed to appear; when judge issued massive summary judgment, Lilly lawyers DID appear and had the judgment set aside on a technicality (improper notification of agent). Then the law firm prevented the lawyer in the case from re-filing/re-submitting (IOW further pursuing) the issue.
The problems are numerous, first and foremost finding a lawyer with the commitment and deep pockets to see the case through. I've contacted several who felt that a case would be winnable, but would require more time and expense than their firms were willing to commit. Ultimately, the lawyer needs to have some "skin in the game"--either feels he, himself, has been abused and harmed by Lilly et al, or has seen a loved one thus abused. Let me know if you can find such an individual. Hubby and I have compiled lots of "circumstantial" information but lack true whistleblower status.
An even more productive approach would be to go after the insulin cartel by using legal means within the criminal division of the FDA or by actually suing the FDA for wrongful approval of a dangerous drug.
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Ever hear of "soft kill" weapons?
Look for it.
Medications, GMO, Mercury that was to be
removed in medications but hasn't, HR 2749
which is total control over food supply.
Don't believe me. Google it.
Agenda 21. Google it.
Somebody want's you DEAD.
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hiii
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