Allies Voice: Insulin - Needful Things and Answered Prayers
For years we've entrusted our health to the powers that be in the oligopoly of Big Pharmaceuticals. Given this caliber of governance over our lives -- shouldn't WE THE PEOPLE be heard in what WE NEED?
There are three big names in the industry of diabetes for insulin: Eli Lilly (NYSE: LLY), Novo Nordisk (NYSE: NVO), and Sanofi-aventis (NYSE: SNY) -- has the industry become complacent? Every time news of someone attempting to enter the market with a revolutionary (keep a close eye on the REVOLUTION segment of this word) concept -- the new competition seems to mysteriously dissolve after the first press release. What goes on?
In 1991, Stephen King wrote a novel called "Needful Things". The story tells a tale of a shop in a small town. One by one, people are drawn to the shop by something they want more than anything else. Somewhere (apparently not too obvious) there is a sign in the store that reads "Caveat emptor" -- which is the Latin phrase for buyer beware.
When shoppers realize that they can't buy the object of their desire, the shop owner offers them a trade - perform a small "favor" for him, in the form of a prank on someone else in the town, and the object is theirs. These betrayals and pranks (some of which deceptively seem to be harmless) cause the town citizens to turn on each other, gradually leading the entire town into complete chaos.
Stephen King has said his inspiration for the story was the decadence of the Eighties: "It occurred to me that in the eighties, everything had come with a price tag, that the decade quite literally was the sale of the century. The final items up on the block had been honor, integrity, self-respect, and innocence... I decided to turn the eighties into a small-town curio shop called Needful Things and see what happened."
The novel ends in the same fashion it began -- in first person narrative where the author is advising the reader to question the underlying cost of "Needful Things" . When the Big Pharmaceutical industry (unanimously) decided in the 1970s to expeditiously release and dominate the market with biosynthetic insulin (for all) -- was this necessarily a "Needful Thing"? If so - for whom? For those of us who never had the opportunity to try different variations of insulin -- natural-source or genetically modified -- why was the decision take away from us? I love living in the land of opportunity. I cannot make a company do anything it has decided it will no longer do -- but I can certainly make a company that does ANYTHING I want it to do. Ask and thou shall receive.
Consider this possibility: You are an owner of a shop called "Prayers Answered". "Prayers Answered" sells insulin -- any insulin you so desire. This is the mother lode of focus groups to make an insulin company -- for the people who use insulin, by the people who need insulin. What are your expectations from the insulin you must use? This is a "wish list", if you will. Where there's a will, there's a way!
My motivation is fulfilling the desires of people living with insulin-dependent diabetes. Desire is the starting point of all achievement. What do you desire from your insulin manufacturer?
- Stephen King's site
- Wikipedia definition of an oligopoly
- Eli Lilly quote from Yahoo Finance
- Novo Nordisk quote from Yahoo Finance
- Sanofi-aventis quote from Yahoo Finance
Please help fund the mission of "Allies Voice" and checkout our featured sponsors. Disclaimer: These ads may not reflect the opinion of "Allies Voice" however these click-through ads PAY for "Allies Voice" to blogcast LOUD AND CLEAR (and free!)
What we (T1DM) Need and Want is not being provided to us by Eli Lilli, Novo Nordisk or Sanofi Aventis.
What I need is Insulin that is affordable, since it is a "Life-sustaining sunstance," the cost should be minimal.
In addition, I need an Insulin that will contain C-peptide so as to provide protection and treatment for Complications that are a part of the Disease Process called T1DM.
I also would like an Insulin based on Nano-Technology whereby exogenous Insulin interacts with circulating Glucose levels just enough w/o causing Hypoglycemia and the excess go to a depository within the Spleen waiting to be "called on."
Reply to this
The potential hurdle (not impossible to get over, either) with C-peptide combined with insulin...
Making the World Safer for People with Diabetes
http://www.AlliesVoice.com
Reply to this
.
(A) What is AnyOne's expectation as regards the effect upon glucose / insulin resistance upon adding C-peptide to Non Human Insulin [NH-Insulin] ... thereby reproducing the way a type 2 Diabetic, producing C-peptide, raises Betacell-Human Insulin [BH-Insulin] production, often substantially, in response to eating / eating too OFTEN?
(
(C) IF glucose / insulin resistance increases upon adding C-peptide to NH-Insulin ... how could You justify the apparent need for increased cost / dosages of NH-Insulin that may result from adding C-peptide?
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.17.FEB.2008 @ 17:00hrs c/o www.LoveDiabetes.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.
Reply to this
For what its worth, our "friends" at Eli Lilly and Company, back in the late 1980's led by Dr. John A. Galloway, actually investigated rDNA production of proinsulin, which contained both the insulin molecule as well as C-Peptide.
However, in 1989, the company abandoned those plans, not necessarily because of adverse events, but because it did not result in a material difference in glycemic control relative to insulin which did not contain C-Peptide. Consequently, Genentech sued Lilly for patent violations for proinsulin production via rDNA -- a lawsuit which Genentech lost -- in 1997.
The bottom line, however, seems clear. The FDA would not see any material difference in glycemic control, so the company concluded it wasn't worth further investment in, because that's the only thing the FDA looks at when it comes to diabetes treatments. Furthermore, Lilly's newest strategy has been to develop a variety of drugs besides insulin which target diabetes complications. Why develop medicines to prevent complications when you can cash in on treating complications and get more bang for your buck?
Reply to this
In general, organisms in the ecosystem are adapted to each other – for example, waste products produced by one species are used by another, and resources used by some are replenished by others; the oxygen needed by animals is produced by plants while the waste product of animal respiration, carbon dioxide, is used by plants as a raw material in photosynthesis. The nitrogen cycle, the water cycle, and the control of animal populations by natural predators are other examples.
http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0015128.html
Making the World Safer for People with Diabetes
http://www.AlliesVoice.com
Reply to this
One final note, Eli Lilly and Company actually invested in research into C-Peptide back in July 1997. Lilly helped fund a joint study with Washington University at St. Louis and the National Institutes of Health, and the company's own researchers discovered that in diabetic rats, treatment with C-peptide reversed vascular and nerve damaged blood vessels and helped to repair them. In the rats treated with C-Peptide, the nerve cells worked normally and vessels almost completely stopped leaking. Obviously, subsequent research at Karolinska has confirmed these findings in humans, too.
Reply to this
A separate vial that just contains C-peptide and would be injected before sleep might overcome some of these hurdles.
Reply to this
.
IS MALE AND/OR FEMALE NH-INSULIN OVER-DOSING >
CAUSED AND/OR SUSTAINED BY LOSS OF ZINC CONTAINING
SEXUAL FLUIDS AND EATING too OFTEN TO COMPENSATE THAT LOSS?
www.CELIBATOR.com
> 1107 www.tinyurl.com/25l6n2 {Melody Hoadley ~ "...Great blog--if anyone will listen. Some prefer NOT to know the truth, nor to even be pointed in the direction to locate the truth."}
Diabetes is caused by eating too OFTEN.
Insulin dependent diabetes apparently requires Non-Human-insulin [NH-insulin] to prevent a HYPERglycemia-Dehydration-Coma
> 0100 www.tinyurl.com/ypozqv {RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom}
Type 2 Diabetic CURED by eating one SUB15 minute meal every day
> 0208 www.tinyurl.com/ypxbyl {"...I started eating less OFTEN and drinking more water. Now I eat 1 meal a day. It's really easy. My blood sugar is normal within two hours of my daily meal."}
Type 1 Diabetic makes a CONSCIOUS lifestyle change for more than 50% reduction in 'Non-Human-insulin' requirement:-
> 0208 www.DrFuhrman.com/disease/Diabetes.aspx {"...a 22 year old college graduate with Type 1 diabetes since the age of 6 ... He was taking a total of 70 units of insulin daily. He was ... having swings in his glucose levels, too high at times and at other times dangerously low. He also wanted to learn more about nutrition to improve his health ... I was impressed by his intelligence and desire to change his eating habits to better his health ... I explained to him that using 70 units of insulin a day was part of the problem ... Over the next two weeks we GRADUALLY TAPERED his INSULIN and found that he only needed 20 units of Lantus insulin at bedtime and 4 units before each meal for a total of 32 units a day. Almost immediately, with my dietary recommendations, his sugars were running in the favorable range, and he no longer experienced dangerous drops in his blood sugar ... I am convinced, that with the EAT-TO-LIVE diet-style, those with Type 1 diabetes can have a long and disease-free life."}
Eating more than ONE MEAL a day is a lifestyle CHOICE that is leading to EXCESS consumption of NH-insulin.
REQUEST: New organically derived NH-insulin - MAXIMally LONG acting - Designed to help prevent HYPERglycemia-Dehydration-Coma - WHEN - Adopting a Diabetic Dietary Protocol [DDP] to help gradually TAPER any NH-insulin doses to a MINIMUM.
When will the first Type 1 Diabetic be CURED by the DDP of eating one SUB15 minute meal every day?
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.17.FEB.2008 @ 14:14hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.
Reply to this
Furious Seasons link: http://www.furiousseasons.com/archives/2007/03/interesting_catie_finding_and_another_example_of_analyst_cognitive_deficit_disorder.html)
Summary of comment: Insulin patent literature had stated that beef Ultralente wasa the " gold standard " for basal control in insulin-dependent diabetes. The combination of antigens/antibodies developed would act as a reservoir in the body. This allowed for maximum efficiency in smooth (plateau-like) "time release" over 24-36 hours. This timeline offered the greatest control to many people with insulin-dependent diabetes throughout the years beef Ultralente was available. Until....
Making the World Safer for People with Diabetes
http://www.AlliesVoice.com
Reply to this
.
ETA?
.
&
How well does this ...
www.tinyurl.cOM/2vh2ul
support this ...
www.tinyurl.cOM/32nqc5
?
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.27.FEB.2008 @ 19:57hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.
Reply to this
.
ANSWERED PRAYERS?
...GLUCOSE / INSULIN RESISTANCE "GIR" IS ALWAYS ... PROTECTIVE?
'...Increasing cellular glucose uptake is a fundamental concept in treatment of DIABETES, whereas nutritive calorie restriction increases life expectancy. We show here that increased glucose SENSITIVITY decreases Caenorhabditis elegans life span, while increased glucose / insulin RESISTANCE extends life expectancy by inducing mitochondrial respiration. The histone deacetylase Sir2.1 is found here to be dispensable for this phenotype, whereas disruption of aak-2, a homolog of AMP-dependent kinase (AMPK), abolishes extension of life span due to impaired glycolysis. Increased glucose / insulin RESISTANCE APPARENTLY promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival rates, altogether providing direct evidence for a hitherto hypothetical concept named mitochondrial hormesis or "mitohormesis." Accordingly, treatment of nematodes with different antioxidants and vitamins prevents extension of life span. In summary, these data indicate that increased glucose / insulin RESISTANCE promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of DIABETES as well as the widespread use of antioxidant supplements...'
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.18.FEB.2008 @ 23:23hrs c/o www.DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.
Reply to this
.
NEEDFUL THINGS?
AUTO-IMMUNE RE-CYCLING OF BETA-CELLS IS A PERFECTLY
HEALTHY WAY OF DOWN-REGULATING INSULIN PRODUCTION
TO HELP PREVENT RELATIVE-HYPOGLYCEMIA-DISTRESS...
ONE MEAL A DAY = LESS INSULIN = MORE BETA-CELL MASS...
> 0402 www.tinyurl.com/2po68s [Duvillie@necker.fr ~ '... insulin reduction = up-regulation of beta-cells c/o increased beta-cell manufacture + decreased beta-cell recycling (aka apoptosis) ... evidencing ... that artificially increasing insulin concentration naturally reduces beta-cell mass & quantity ...'].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.19.MAR.2008 @ 23:50hrs c/o www.DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDARIAN.com
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.
Reply to this
.
ANSWERED PRAYERS?
LEVELS OF GHERLIN WERE ELEVATED IN RESPONSE TO ONE-MEAL-EVERY-DAY...
Increased glucose / insulin RESISTANCE [GIR]promotes mitochondrial metabolism ... cumulating in HORMOsis and extension of life span.
> 1007 www.HORMOsis.cOM [MRistow@mristow.org] ~ Michael Ristow]
ONE MEAL A DAY = MORE TSG = MORE BETA-CELL MASS...
> 1107 www.tinyurl.cOM/3akf92 [MattsonM@grc.nia.nih.gov ~ '... Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
An issue in the field of diet and health is if and how changes in meal frequency affect energy metabolism in humans. The influence of reduced meal frequency without a reduction in energy intake on glucose metabolism was evaluated in normal-weight, healthy male and female subjects.
The study was a randomized crossover design, with two 8-week treatment periods (with an intervening 11-week off-diet period) in which subjects consumed all of their calories for weight maintenance distributed in either 3 meals or 1-meal-per-day (consumed between 4:00 pm and 8:00 pm).
Energy metabolism was evaluated at designated time points throughout the study by performing morning oral glucose tolerance tests and measuring levels of glucose, insulin, glucagon, leptin, gherlin, adiponectin, resistin, and brain-derived neurotrophic factor (BDNF).
Subjects consuming 1-meal-per-day exhibited higher morning fasting plasma glucose levels [Transient Supernormal-Glycemia (TSG)], greater and more sustained elevations of plasma glucose concentrations, and a delayed insulin response in the oral glucose tolerance test compared with subjects consuming 3 meals per day.
Levels of gherlin were elevated in response to the 1-meal-per-day regimen [www.GHERLIN.cOM].
Fasting levels of insulin, leptin, adiponectin, resistin, and BDNF were not significantly affected by meal frequency.
Subjects consuming a single large daily meal exhibit elevated fasting glucose levels and increased morning glucose / insulin RESISTANCE & tolerance associated with a delayed insulin response during a 2-month diet period compared with those consuming 3 meals per day {who were less able to resist sudden increases in glucose into their cells (less GIR)}.
The increased glucose / insulin RESISTANCE & tolerance was reversible and was not associated with alterations in the levels of adipokines or BDNF. ...'].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.20.FEB.2008 @ 22:33hrs c/o www.DiabetesHealth.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
Reply to this
For those using pig insulin:
-How do your daily doses compare to using "Human" insulin?
-Has your ability to detect hypoglycemia improved?
-How many injections per day do you take, and what is your control like?
-Have your hypoglycemic episodes gotten worse, stayed the same, or improved?
-Did you develop lipotrophy or hypertrophy?
-Does animal insulin last as long (less preservative?)
-If you "feel" better, can you describe how?
-Do any of you use animal insulin in a pump?
-Have any of you had a positive c-peptide test *after* starting animal insulin, and/or how were your antibodies affected?
Thanks in advance to anyone who can answer this.
Also, if you're in Canada, how much does your insulin cost? I have all of my pump supplies, strips, GM insulin. etc. covered by my province after I pay 3% of my income, but I am guessing animal insulin is not covered. My dessicated pig thyroid is not, but Sythroid and Cytomel are.
Thanks.
Reply to this
Sarah,
I'm switching to porcine shortly (I bought my 1st supply through Canada but haven't switched yet.) The research evidence out there is pretty good on some of your questions, namely:
- The daily dose should be the same.
- hypo detection should be improved (sweating is more noticeable).
- Control should be the same (as evidenced by A1C level.)
- Lipotrophy is virtually non-existent with all highly purified insulins, including porcine, which actually is slightly more pure than GE human.
- The preservative levels are 22-44% lower for m-cresol and phenol as compared to Detemir and Glargine (I'll be posting a research review on this shortly - Brent got me going on it).
I say "should be" as opposed to "are" the same because everyone's make up is different in the end. For me, Humalog is pretty much expended in my system by 1.75 hours, which isn't what the research says will happen and my endo refusesto believe me. But, facts are facts and that's what it does in my body.
I wanted to add another question to your list for those out there who are using porcine already:
- Did you test for any antibody levels on a quantified level before and after starting porcine to get a comparison?
- Which tests did you do?
- Why? and,
- What were your results? The research out there is all over the place on this one. It looks like most research says GE human is slightly less immunogenic than porcine, but I doubt the power of the studies was sufficient to make the statements made in virtually all papers I've read and some are pro and some con anyway. I'd love to hear any feedback out there.
I have been researching this topic for a long time and still can't make heads or tails of whether or not any testing would be helpful or useful. Regardless, I'm making the switch by the end of the month for 2 reasons not mentioned in your post: decreased risk of carcinogenicity and decreased levels of m-cresol and phenol as compared to Detemir and Glargine. I put out a comparison review of insulins on Allie's former blog, The Diabetes Blog, and think I can repost it here if you're interested (it has all my references).
Kelly
Reply to this
Hi Kelly........What is the cost for the porcine Insulin? Does the vial have a 28 day longevity?
Is both short acting and basal made separately?
Thanks.
BetterCell
Reply to this
I also just ordered my first bottle of porcine from canada, its for my 14 year old so. I have been very stressed lately since they have just switched him from humalog to novalog and one of the ingrediants alarmed me. Also, his moods are very aggressive and angry. I am hoping someone can help give me insight on the porcine insulin and want my son to have a more normal behavior and sence of peace. He also has very poor focus and memory. He became diabetic at the age of 17 months after his series of vaccines and the MMR shot. Any advice??? Robin
Reply to this
Hi Robin,
I also got type 1 diabetes from the MMR vaccination. I totally understand what you both are going through. My website is: www.diabetesdoneright.com.
My best, Julie
Reply to this
Robin.....Your son's moods could be related to his glucose(high and low) levels as well as changes in sex hormones related to his developing teen years and absolutely nothing to do with the type of insulin he is using.
Reply to this
Anger in a type 1 diabetic is most likely related to hypoglycemia, since this stimulates release of cortisone and other stress hormones from the adrenal glands, and adrenal gland hormones are known to produce anger and irritation. I have never seen any literature that hyperglycemia can affect mood, however.
Reply to this
I agree, that anger can be a reflection of Hypoglycemia. However, I do not need a Journal to document and validate emotional levels in me as person w/T1DM when I have either Hypoglycemia or Hyperglycemia and mood effect as a consequence of this disequilibrium within the body.
Reply to this
Ditto.
Kelly
Reply to this
Robin,
I'd encourage you to follow your instincts. You know your son. If you think it's caused by the insulin, I'd put my money on it that it probably is. I found when I switched to porcine that my moods and quickness to anger definitely improved. I feel less fatigued and spaced out. The porcine wasn't like a miracle cure, but about 3 or 4 weeks after I started taking it, I realized I just wasn't as fatigued and sleepy as I had been before (on Ultralente). I had notably more energy. It's been about 3 months now, and the same sense has continued.
I have no doubt that insulin clouds my head and that different types act differently in my body. If, when your son changed insulin types, you noticed a change in his behavior, that doesn't sound to me like it's because he's 14, as BetterCell suggested. It sounds much more directly related to the insulin switch. I'd trust your instincts, talk with your son about what you think you're seeing, and encourage him to do his own research and trust what he thinks his body is telling him. He's not too young to take charge of his health. It can be a helpless feeling, feeling like you're not in charge of what's being injected in to your own body. Of all the things I've done since I became diabetic, the one thing I regret, is not focusing my energy right from the get-go on my own original diagnosis and changing the course that the doctors put me on. Just because they "say it's so" doesn't mean it is - it only is if you believe them and buy into it.
I'd also you to encourage him to think of his condition as an "injury" as opposed to a "disease" if he isn't already. For me, that made a big difference in my head about what I thought of my body and whether or not I thought I could help it heal. (My condition was also an injury, caused by an antibiotic.)
Best wishes,
Kelly
Reply to this
Raging sexual hormones in a 14yr old male exist and the subsequent "mood" affect.
I remember them(fondly).
Reply to this
Robin - WELCOME! You are an *amazing* parent for wanting "normalcy" for your son. The affects imposed from insulin analogues have been dismissed as "patient" misgivings. Parents and people who know their bodies - and what feels right and what IS wrong - seek answers. Thank you for questioning "conventional" bad medicine. Please let us / me know how things turn-out for your son on pork. I wouldn't give up mine for the WORLD -- but I'd love to get it to the market here in the US as SOON as possible. We ALL need a CHOICE other than genetically modified analogues.
Best,
Allie
Reply to this
Thank you for your support of my search for answers. What should be a readily available option for my son here in the US, I have to cross the borders to obtain. He was put on the pump and Humalog 2 years ago. He looks emaciated and has horrible moods. All I know is I need to try to find an answer! Robin
Reply to this
Sarah et al.,
I just noticed that it looks like Allie accidentally posted her very helpful response to your questions in her other piece, "Allies Voice: Hundreds of thousands squandered from JDRF". Definitely, check it out if you didn't catch it already.
Kelly
Reply to this
Thanks for your input, both Allie and Kelly!
I actualyl did indirectly address the preservative issue ("less preservatives?)...I agree with your thoughts Kelly regarding potential carcinogenic properties of certain GM insulin, either due to the change in amino acid structure or preservatives. I know that one long acting insulin prior to Lantus was scrapped in animal trials due to increased cancer risk.
I am wanting to try pork insulin (the only kind available in Canada), my only apprehension is possible increased lows. Since using the analogues (Novorapid is out of my body in 3.5 hours or less), my severe lows and frequnecy of lows was somewhat reduced. This was further reduced on the pump. I have not had a seizure or very severe low (i.e. needing 3rd party help) since being on the pump.
I am very insulin sensitive, so that and cost are my only concerns. I would be using Regular (only) in the pump. I would not go back to injections, since my seizures all occurred using NPH and even the porcine NPH may be too unpredictable. I just wouldn't risk it. The pump is great for precise dosing too.
I am a little scared to go back to Regular, but I feel that it is worth the try. I just wanted to get some personal experience stories before I take that step. My next move is to find out if porcine insulin is covered by my provincial Pharmacare program. I doubt it, but it would certainly help. Fingers crossed!
I also forgot to ask one more question...If any of you have complications, did you notice a clinical improvement in your complications (i.e. neuropathy)or in standard testing?
I am lucky in that I don't have any (detectable) complications yet after 24 years of T1, but I don't think my luck is going to last forever. Preventing complications would be a major reason to switch. Since I have had T1 almost my whole life, I know I am on borrowed time...
Thank you so much for everyone's input!
Sarah
Reply to this
Hi, Wow, I am facing the same issue and have just ordered my first bottle of porcine insulin for use in a pump, any information about your experiences is greatly appreciated. My son is 14 and has had diabetes for 12 years. Robin
Reply to this
Sarah,
That you are very insulin sensitive means your pancreas is still working. NPH is a horrible product - it's so peaky in its action that avoiding lows is practically impossible. I've only used it twice, when I first was diagnosed, and then when I was pregnant, before entering labor (so I wouldn't have a lot of long acting insulin on board.) Other than uses like that, it's a useless insulin in my opinion.
If you are very insulin sensitive, have you ever tried reallllly shifting your diet to get off insulin entirely? I've been impressed with how much I've been able to eliminate insulin based on a low inflammatory diet. If you're not taking an long acting insulin and your super sensitive to short acting, I'd try getting off insulin entirely.
On the porcine isophane, I've found that it's action profile is quite smooth. It isn't peaky like the NPH, not at all. I don't really notice any peak.
On complications, I've been diabetic for 20 years, but have none. And I don't think I'll ever have any. I wouldn't personally "teach" your brain to expect complications, that you're "on borrowed time." Why assume the worst?
Kelly
Reply to this
Allie, if someone is selling false hope and promoting *personal sales* on your website via links, does it violate the rules of your website?
Reply to this
.
www.tinyurl.com/2w7gp9
.
Vernon Howard's
SECRETS OF LIFE (R)
**********************************************************************
"The banquet is always on the table, but hungry Men and Women refuse to approach."
1500 Ways to Escape the Human Jungle, # 81
Go to the Bookstore link at http://www.anewlife.org/html/home.html
**********************************************************************
Visit the SECRETS OF LIFE Archives of Vernon Howard quotes:
http://archive.mail-list.com/secretsoflife
**********************************************************************
Share Vernon Howard's SECRETS OF LIFE with a friend!
Forward this message to those you know who are also searching
for the answers to life, or copy a past quote from the archives
to e-mail them.
**********************************************************************
.
Reply to this
.
needful CHOLESTEROL = More Stress Resistance = LIFE or More ... HOW ?
video >
www.NicholasDynesGracey.blogspot.cOM/2008/03/cholesterol-more-stress-resistance-more.html
< video
MONitoring trends In CArdiovascular disease ? MONICA ... WHO ?
www.Love-Cholesterol.cOM
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.09.MAR.2008 @ 17:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO=thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2hht4z
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.Intermittent-Fasting.cOM
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/299t3f
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is NOT a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.
Reply to this
I am confused on the C-peptide developments. It seems so simply. C-peptide is already in body for non-diabetics. It has been researched for at least 10 years by companies. Why isn't anything happening. Creative Peptides partner Swartz walked away in 2001.
What is happening?
Reply to this
Hi Peter......C-peptide has a long Bibliography going back at least to the 1970's and has shown by a good number of Researchers to be both protective against many Complications associated with T1DM as well as
having a therapeutic role in management as well.
Ehe answer to the "Why" that you pose
has to do with $$, like most things.........Unfortunate.
Reply to this