Allies Voice: Performance enhancement or damaged goods?
ESPN calls today's Capitol Hill hearing on HGH use in Major League Baseball "Damaged Goods", but I call it resoundingly familiar in the fairytale I know as "diabetes control". These guys were just trying to obtain physical excellence any way they could obtain it to put a smile on the fans faces and please their coaches. Controlling diabetes is really no different - especially nowadays when everything is performance enhanced. Looks like major league baseball isn't the only legacy with damaged goods.
Once upon a time insulin therapy was a lot easier. The job of managing diabetes was actually easier because you didn't have all of the "performance enhancement" options - satellite glucose monitoring, unleaded premium patented Franken insulins, and infrared frequency controlled pumps. This is because we're all trying to impress our doctors with nothing but homerun numbers.
How is this any different than professional athletes looking for "performance enhancements"? The way I see it - athletes are only doing what their coaches tell them to do to keep their bosses happy, the fans happy - and win games. Is this any different than a patient with diabetes taking what their doctor says is the best for their glucose performance? We want to keep our doctors happy and win the game too, right?
Back in the day (circa 1983 and before) you could bet in a tight range your insulin efficacy. You also had confidence in knowing your insulin would be around for more than just a few years. In recent testimony before Congress discussing generic biotech pharmaceuticals, a Novo Nordisk representative stated they will eventually move on to all analog "insulins." If you take a look at history, based on this statement, consider the statement that in 1993-94, Beef Ultralente was removed from the marketplace and the removal of ALL natural insulins took place over the ensuing decade. Then also based on history, Human Ultralente (which was the replacement for Beef Ultralente) was also removed from the marketplace during this timeframe.
If you are new to insulin - as in the last 5 years or so - you'll start to notice a fleeting trend when you cozy up to insulin you think works best for you. Newer drugs are always in the pipeline at the pharmaceutical companies. It's a shame, but the only thing that has remained consistent in the drug market of diabetes is the life-saving glucagon shot. Life-saving if it's not the last $100 in your pocket. A glucagon kit costs anywhere from $75 to $250! I want to thank Bernard Farrell for bringing that ugly truth to my attention. Why do you have to pay so much for something that should be feasibly available, if not partnered with the danger itself?
Here's a riddle for the thinkers: Now we are coming to that period of time where the processes for making Human Insulin (Humulin, Humulin NPH) will be losing patent protection. We must realize that it is the PROCESS--not the product-that is afforded patent protection. Biotech companies are placing pressure on the FDA/government to allow production of this "common" hormone. Acting as obstructionists, the current insulin cartel is imploring the FDA to REQUIRE bioequivalence testing for generic manufacturers, disregarding the fact that they, themselves, have never been held to this standard. How does one resolve such voodoo economics? Anybody? Anybody? Bueller? Bueller?
Brent Hoadley, the author of "Too Profitable to Cure"", had a few ideas as to where Big Pharmaceutical might run interference and their usual shenanigans (yes, I love italics). Some might also call it diabusiness - either way, it affects us all.
Who's to say Novo and Lilly won't decide to take their ball and go home. This leaves the FDA with nothing to use for bioequivalence of the product or chemical identity to the product no longer in the marketplace. At this point, biotech companies have no other option but to work on and patent new insulin-like compounds. Unless, of course, the best diabetes drugs of yesteryear were actually NOT drugs at all...but natural insulins. Last time I checked the polypeptide sequence of bovine or porcine (beef or pork) insulin and the concentrations of zinc or protamine for Regular or NPH - it looked the same as it ever was! :::Queue the music:::
- Support "Allies Voice and SUBSCRIBE - it's free!
- Congress moving on generic biotech drugs
- ESPN news on "Damaged Goods"
- Today's Ode to Ben Stein
- Brent Hoadley, author of "Too Profitable to Cure""
- Bernard Farrell, software developer and diabetic gadget review, brought to my attention the insane cost for glucagon.
- Unreasonably priced glucagons kits
- Talking Heads: Once in a Lifetime
Yeah the Cost of Insulin has not dropped a Single Cent in over 30 Years* I think it was about $18 Bucks way back when + is about $22 now - thass Ridiculous but I guess if Peeps are used to Coughing up a $20 Spot + don't Complain - they will continue to Gouge us*
I think we should All just Quit Taking it!! That'll Show 'em!!
;PPP
Your Glucagon analogy reminded me of those Bee Sting Kits for an Adrenaline Shot - again $75 Bucks!! Who the Heck besides Fat Pharmaceutical Execs can afford that! I am Allergic to Mustard + Dill - which fortunately I can Avoid but if yer Eating out in a Resto - Mustard is buried in Everything to Zip it up!
Also fortunate is having Benadryl + if taken Early enuf it will do the Trick but sometimes U do need an Epinephrine Shot to clear it out Immediately - especially Folks allergic to Peanuts or ShellFish.
Will U be doing any more Posts on bOOb Size + Diabetes??
I loved that!!
Cheers Folks! Billy
Peace*
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Oh I almost forgot - Why are these Mangy Curs going after Roger Clemens like Rabid Dogs instead of Bush?
Ridiculous*
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Vernon Howard's
SECRETS OF LIFE (R)
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"Keep your questions short and clear; do not give a speech. Do not
talk because you love the sound of your own voice and when you talk
and ask a question, know that you're talking, hear the sound of your
voice, know the rate of speed at which you are talking, watch your
mind operate as you are talking. And if you watch closely enough,
you'll be able to see thoughts come right on up and form into words.
You'll also see a choice of words, of thoughts, of ideas coming up
and right in front of your own mind. You'll be able to allow that
one to come into a word instead of that one. It's a very interesting
experience."
Questions and Answers DVD # 29, Talk 3
Go to the Bookstore link at http://www.anewlife.org/html/home.html
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We have already reached the point where the processes for making Human Insulin (Humulin, Humulin NPH) have lost patent protection. For Humulin R and Humulin N, the patents expired in 2001. For Novolin R and Novolin N, those patents expired in 2002, so anyone can now copy the processes used to make them.
Also, insulin being grandfathered under the Federal Food, Drug & Cosmetic Act (not the Public Health Services Act which governs most other biopharmaceuticals) means there is no legal impediment to generics RIGHT NOW. But the FDA has refused to outline procedures for generics manufacturers to get approvals. The law isn't holding this up, it is policy at the FDA.
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IS MALE AND/OR FEMALE DIABETES >
CAUSED AND/OR SUSTAINED BY LOSS
OF ZINC CONTAINING SEXUAL FLUIDS?
SEX-DAY PERFORMANCE ENHANCEMENT OR BIRTH-DAY?
> 0896 www.tinyurl.com/3b5hsr [Gisela.Dahlquist@pediatri.umu.se]
> 0208 www.tinyurl.com/2dmqk8 [Ian.MrTao@Gmail.com]
HAPPY VALENTINE'S DAY.
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.14.FEB.2008 @ 22:32hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
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"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [Relative-NormoGlycemia (RNG)]... www.tinyurl.com/2guhfd
CURED diabetes [Relative-HYPOglycemia-Distress (RHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
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Well I just placed an order in for well the insulin that is keeping me alive and believe me there is no other option for me and I refuse to inject anything else into my body other than animal insulin but guess what here is the cost so far, $25.00 dollars to mail the order to England, $4,280 dollars US because the pound today is 1.97 to every dollar not to mention the extra $60.00 dollars to have TNT deliver it to Customs or or the FDA and well that will take a couple of weeks for sure so let's see know for a 6 month supply of insulin that is keeping me alive is $4,400 plus or minus a few dollars. This is place on my credit card which will be maxed out shortly just to get the very medication or hormone or what ever you want to call it. For it's all or nothing. Please tell me any other medical condition that requires so much paper work, hassle, stress, and expense just to live a somewhat normal life. I just want to thank Eli Lilly and Novo and all the rest who failed the Diabetic population the option of choosing what is good for them. Thank you for all your help. :0
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sorry for the offtopic question but,
have you heard of an insulin still with c-peptide still intact? Any bovine or porcine insulin produced somewhere outside USA?
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Glenn--My last order had an additional $60 cost to get TNT to deliver the product to my door. (The first $60 TNT charge was noted on my invoice; the second $60 charge occurred when I called to find out when my shipment would be cleared through customs and shipped to me. I was informed there was an additional $60 delivery charge--and required to supply credit card info to complete the transaction. In almost any other area, this would be called EXTORTION.)
And you have failed to explain the stress caused by delivery uncertainty: (1) will the shipment survive high-altitude transit (one of my shipments had four bottomless, empty vials); (2) will shipment be stored at proper temperature; (3) will customs clearance go smoothly--or will this be the shipment where Dept. of Homeland Security steps in and confiscates my "illegal" drug--BECAUSE THEY CAN?
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In response, to Glenn V and Melody, I am so disgusted to hear how difficult it is for you to get your insulin. Is there anyone out there that can help? Allie, can you help them? It is not only vital that they receive their insulin, but that it is not damaged because of temperature changes, etc.
My heart goes out to both of you. I will be praying and placing a call to heaven. Again, I am so sorry to hear this.
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Apparently, it doesn't look TOO hard to get porcine insulin in Canada, as long as this statement below is current. Perhaps it would be easier for some Americans to order their insulin from here instead of the UK?
http://www.diabetes.ca/common/PrintVersion.asp?ID=45482
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Sarah,
It's easy to get porcine insulin through Canada; they've been very helpful to me. You can get it directly online without a doctor's prescription. IDDT.org says you can drive over the border to physically buy it; but, I haven't had luck yet in finding it.
To make an online purchase, you can go to http://www.getcanadiandrugs.com. When you sign up for a user's account, they require you to sign that you've used the drug before. I haven't used it, although I do have a prescription so I called the company to ask what to do. They told me to click "I agree" anyway.
Through getcanadiandrugs.com, it costs $131.99 U.S. per vial plus (for me at least) $14.99 U.S. in express "cold" shipping. They say on the website it takes 8-14 days, but when I called them, they told me it's closer to 3-8 days depending how long it gets delayed in customs.
Through the manufacturer, Wockhardt, you can get each vial for $25 pounds (or $49.17 U.S.) but that excludes the USDA permit ($94 U.S. for a 1 year permit, $61 U.S. per year to renew), administration costs ($98 U.S. per order) and shipping costs ($114 U.S. per order) which for 6 vials adds up to $1,085 U.S., which equates to $180/vial at a minimum, so it's a lot cheaper to go through getcanadiandrugs.com.
Another consideration is, with Wockhardt, you have to jump through the hoops (there are 5), including getting a physician to write a letter of medical necessity and sign Wockhardt's "Compassionate Use" form (which is anything but compassionate and will need an understanding physician to sign).
I've opted to go through Canada.
Kelly
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My apologies. My math was in space. The correct comparison is:
With Wockhardt, 6 vials would total:
Insulin: $49.17 x 6 = $295 (in U.S. dollars)
USDA Permit: $94 (lasts 1 year, $61 to renew)
Admin & Shipping: $216
Total Wockhardt for 6 vial order: $601, or roughly $100/vial. This drops to $84/vial on your second order if you order twice per year (no USDA permit cost). This by the way also excludes the additional $60 fee I've heard assessed to have the insulin shipped directly to your house instead of to your doctor's address. See the Export section at www.wockhardt.uk.co for a list of their requirements (there are 5: a letter from your doctor for medical necessity, a letter you write saying it's for personal use and doesn't exceed a 6 month supply, a "Compassionate Use" form signed by your doctor, the order form, and the USDA permit.
With buycanadiandrugs.com, 6 vials total as follows:
Insulin: $131.99 x 6 = $791 (in U.S. dollars)
USDA Permit: $0 (it's not required but infrequently the insulin will be held by customs)
Admin & Shipping: $14.99 (but varies by location)
Total buycanadiandrugs.com for 6 vial order: $806, or roughly $134/vial.
No prescription required. No doctor's letter required. No "Compassionate Use" form required.
Lastly, I confirmed that Wockhardt's Hypurin Porcine Isophane insulin is sold in Canada under the name Hypurin Porcine NPH. They are the same product.
My apologies again for any confusion.
Kelly
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Thanks. I actually AM Canadian, and live in Canada. Lucky, I know! I'm trying to help you guys!
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Sara,
Thanks. That's great! Do you know if/which pharmacies in B.C. actually carry porcine insulin? I'd drive over the border if I knew where to go...
Thanks,
Kelly
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IS 'MASTURBATION' SUSTAINING 'DIABETIC'
TYPE HYPERGLYCEMIA BY CHRONIC LOSS
OF ZINC-CONTAINING SEXUAL FLUIDS?
SEX 'DAMAGED GOODS' and/or UNSTABLE BLOOD GLUCOSE?
> 0407 www.tinyurl.com/2odhdo {Masturbation video illustrating extreme sexual fluid loss and concomitant potential ZINC deficit induced alpha-cell HYPERglycemia -- There is a different outcome between alpha-cell glucagon ... stimulated relative-HYPERglycemia [EG a horror movie (www.tinyurl.com/2opc5h)] ~ VS ~ eating too OFTEN ... caused acute relative-HYPERglycemia [EG a cake (www.tinyurl.com/32dvnb) and a combination of both in the form of LOSS of sexual fluids as per the referenced video about masturbation.}
> 0407 www.tinyurl.com/2oonjv {'...We propose that during HYPOglycemia the principal signal that initiates glucagon secretion is the detection by alpha-cells of a sudden decrease in ZINC ... stimulates glucagon secretion.'}
> 0108 www.tinyurl.com/yrd6u {Alpha-cells & Epsilon-cells (www.tinyurl.com/2psoy3) secrete ghrelin which inhibits beta-cell insulin release & stimulates growth hormone release from the anterior pituitary (www.tinyurl.com/3exose) AND alpha-cells secrete glucagon which stimulates glucose production in / release from ... the LIVER ... into the blood.}
> 0108 www.tinyurl.com/38c2ek {"...For the record, I am a practcing Catholic who waited until sex for marriage...unlike Ms. Berry. And yet she is "cured" and not me...go figure..."}
> 0208 www.tinyurl.com/24sls8 {continent ~ VS ~ incontinent ... Masturbation causes BOTH females & males much loss of sexual fluids ... but this article highlights the female potential to actively absorb the male fluids which may hint at potential reason for female / male differences in lifespan.
HOW INCONTINENT HAVE YOU BEEN?
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.15.FEB.2008 @ 19:45hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
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"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
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PERFORMANCE ENHANCEMENT?
INTERMITTENT-FASTING HELPS PREVENT DIABETIC NEPHROPATHY...
Intermittent fasting increases glucose / insulin RESISTANCE [GIR] which promotes mitochondrial metabolism cumulating in HORMOsis and extension of life span.
> 1007 www.HORMOsis.cOM [MRistow@mristow.org ~ Michael Ristow]
> 0503 www.Intermittent-Fasting.cOM [Anson@jhu.edu ~ Michael Anson]
ONE MEAL A DAY = MORE GIR = LESS DIABETIC NEUROPATHY...
> 0307 www.tinyurl.com/2nof9z [Tikoo.K@gmail.com ~ '... Intermittent fasting prevents the progression of type 1 diabetic nephropathy in rats and changes the expression of Sir2 and p53.
Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160 062, India.
Diabetic nephropathy (DN) is one of the main causes of KIDNEY disease and a leading cause of diabetes mellitus related morbidity and mortality.
Recently, SIRTUIN are reported to have emerging pathogenetic roles in cancer, muscle differentiation, heart failure, neurodegeneration, diabetes and aging.
The aim of the present study was to study the role of intermittent fasting (IF) on DN and studying the expression of SIRTUIN ... Sir2 and p53.
At biochemical level, it was found that IF causes significant improvement in blood urea nitrogen (BUN), creatinine, albumin and HDL cholesterol, parameters that are sometimes associated with the development of DN. There parameters suggest that DN may be in-progress but it is other than clear which of the parameters are part of a healing process helping to combat developing DN.
Diabetic rats on IF also show significant, apparently beneficial, changes onset of hypertension.
Interestingly, the expression of Sir2, a NAD dependent histone deacetylase, decreases in diabetic rat kidney and this decrease is overcome by IF.
Evidence is also provided for involvement of mitogen activated protein kinases (MAPK) cascade in mediating the effects of IF as there is reduction in the expression of p38 which gets induced under diabetic condition. This was further accompanied by a decrease in p53 expression.
These findings suggest that IF, by way of a 'One Meal every day' (SUB15 minutes) intermittent-fasting program, should slow, halt or reverse the development of Diabetic neuropathy...'].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.21.FEB.2008 @ 17:27hrs c/o www.DiabetesHealth.cOM & www.HYPO-thesis.cOM
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"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
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HOW PERFORMANCE ENHANCEMENT?
ONE MEAL A DAY = MORE GHerlin = LESS DIABETIC NEUROPATHY ...
'...Synaptic changes induced by GHerlin are paralleled by enhanced spatial learning & memory. Tamas Horvath, Chairman of Yale Medical School's comparative medicine program says We can use the hormonal discoveries to our cognitive advantage. In each case, the biochemically “hungry” mice ... performed notably better than those with normal levels of the hormone. The finding was startling, but “it makes sense,” Horvath says. In fact, some Biologists believe that human intelligence itself evolved because it made early Hominids more effective Hunters, Gatherers and Foragers ... Facing the LSAT, a final exam or a half-day job interview? Go in mildly hungry, not carbo-loaded ... and ... maintain that edgy state. Such advice, applied on a national scale, might help save our schools...'
> 1206 www.GHerlin.cOM [Tamas.Horvath@yale.edu ~ Tamas Horvath (www.tinyurl.com/2fb4x7)]
> 0503 www.Intermittent-Fasting.cOM [Anson@jhu.edu ~ Michael Anson]
INTERMITTENT-FASTING IS NEURO-PROTECTIVE ...
> 1203 www.tinyurl.com/35ehxx [YTache@mednet.ucla.edu ~ '... GHerlin: a novel player in the gut-brain regulation of growth hormone and energy balance.
St-Pierre DH, Wang L, Taché Y.
Faculty of Medicine, Department of Nutrition, Université de Montréal, Montréal, Québec H3C 3J7, Canada.
GHerlin is a newly discovered peptide hormone produced by the stomach that displays potent growth hormone-releasing activity and a stimulatory effect on food intake and digestive function while reducing energy expenditure.
The isolation of GHerlin has led to new insights into how this gastric hormone links the endocrine control of nutritional homeostasis with growth hormone secretion ... through gut-brain interactions.
In adult humans, plasma GHerlin levels rise twofold before a meal and decline to trough levels within 1 h after eating. Likewise, GHerlin levels are elevated by fasting and decreased after refeeding in rats.
In human obesity, GHerlin level is low, which may be related to the high caloric intake, whereas reduction of body weight in obese patients brings the GHerlin level up.
Interestingly, although GHerlin levels are reported to be high in patients undergoing diets, stomach bypass surgery decreased GHrelin levels, suggesting that the size of the stomach may be directly correlated to GHerlin levels...'].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.22.FEB.2008 @ 20:23hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
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"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
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One performance enhancement is primarily about the money, and secondarily about the history. Of course a player wants in the hall of fame, but the primary concern is to get set up in the hear, now, and foreseeable future. The hall of fame is primarily for one's children, grand-children, great-grand-children....
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