Allies Voice: Could Delta Force explain diabetes?
Whatever your type of diabetes - the diagnosing precursor is elevated blood glucose. Scientists have known about beta cells secreting insulin to lower blood sugar. They know about alpha cells raising blood sugar, too. So why is it in modern day scientific glory - we have conveniently ignored the importance of delta cells?
Type 2 diabetes is caused by insulin resistance. The resistance is brought on by excessive C-peptide in the body. C-peptide and insulin are produced in the beta cells and released when glucose in the blood needs to enter the cells of the body to be turned into energy. Thank you Kreb's Cycle!
However, there is another type of cell that may be the culprit in Type 2 diabetes. These cells are called the alpha cells. Alpha cells release stored glucose from the liver when the brain signals the body that there is a deficit of available glucose in the blood. What is the guiding force that told the brain there is a deficit? We'll get to that in a moment - first let's look at Type 1.
The nature of Type 1 is great defense. A person with Type 1 diabetes is up against a team that knows every play before the kickoff. No matter how hard we strategize to get the insulin into the end zones - we're up against one of the greatest teams to hit the field. :::::: GO GIANTS!!!!!::::::
The person up against Type 1 diabetes has their defensive linemen warming the bench. These players are supposed to defend the offensive linemen (our islets) against Type 1 diabetes. These defensive linemen are called TNF-alpha. People with Type 1 have precipitously declining levels of TNF-alpha.
So how do we explain the phenomenon of elevated blood sugar if we ignore an MVP?
Like the pause button- somatostatin is excreted into the blood when the blood sugar needs to be frozen in the perfect range. The cells that excrete somatostatin are called DELTA CELLS. The name is significant because these puppies are as significant as the gravitational pull on Earth! Somatostatin is excreted from locations throughout the alimentary canal like the stomach and the intestines, as well as the delta cells of the pancreas. Makes perfect sense, doesn't it? If you plan to effectively regulate blood sugar - you must be on your A game at the points of entry!
Somatostatin was first identified as a hormone that inhibited secretion of growth hormone (i.e., hit pause, please). It regulates the endocrine system, affects neurotransmitters (triggering or suppressing appetite hormones), as well as governing cell growth. Didn't I say the DELTA CELLS were significant?
That old saying "use it or lose it" is a beautiful witticism in this case. Beta cells are gradually put to rest under the influence of drugs. This is exactly why some Type 2s become insulin-dependent over time. Alpha cells become less responsive, as well. Many people with Type 2 experience dangerous lows and blackout after starting drug treatment for diabetes. But what about the starring quarterback - the DELTA CELLS?
Diabetes treatment is as crazy as that astronaut woman that wore diapers to cross the country and assault her romantic rival. Why are we treating diabetes by impairing our ability to regulate blood sugar? We are enabling our bodies to destruct our blood sugar regulating system. Don't despair - your accomplices to the crime of diabetes know not the damage they cause. The paint-by-numbers protocol for diabetes says nothing about DELTA CELLS. It would be a shame to see this GAME OVER.
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- Description of somatostatin
- Cytokine activity influencing alpha, beta and detla cell sensitivity
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2/10/2008 12:09 PM
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Thanks for asking the questions. My son has had D for 8 years. It is only recently that I have taken more of an interest in why. Thanks to your blogging, my endo is going to have a lot of questions to consider tomorrow at our appointment! Keep asking those question, Allie.
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Excellent Post Allie!!
We are Finally getting down to the Cell level in terms of determing the Cause of Diabetes + Most Importantly Finding a Cure!
Whether the Cure will come via Embryonic Stem Cell Research or some other Cells who knows but the Important thing is we don't turn a Blind Eye like Bush + his Brainwashed Flock to this Science!
I read an interesting thing on http://www.LifeSharers.com/ about Donating Organs First to People who have had the Brains to Fill out the Organ Donor Card.
"By joining LifeSharers you will also make the organ transplant system fairer by helping registered organ donors get their fair share of organs. About half of the organs transplanted in the United States go to people who have not agreed to donate their own organs when they die. That's not fair, and it's one of the reasons there is such a large organ shortage.
Join LifeSharers now. It's free. It could save your life. Everyone is welcome to join. There's no age limit, and no one is excluded due to any pre-existing medical condition. Once you've joined, you can sign up your children as well."
I think that would work Great for Embryonic Stem Cell Research - Fine if U oppose it then U + any of yer Family Members Step to the Back o the Bus when the Amazing Cures start coming Now + over the Next 10 or 20 Years!
Peace*
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Allie, do you really think tat anyone is interested (R&D and Pharmaceuticals) in the inquiry into Delta Cells.
Whatever happened to C-peptide? I think that you should want to speak with Researchers into making this available as an additional "Tool" in the Management/Prevention of Complications that exist in T1DM (controlled AND uncontrolled Glucose Levels).
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www.TheDiabetesBlog.com/2007/05/28/a-memorial-for-the-islets-of-langerhan
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You make a good point, namely because most researchers are fixated on beta cells. However, in type 1(a) diabetes mellitus, we know that islet cell antibodies destroy EVERYTHING contained in those little islands which comprise less than 2% of the pancreas: beta cells which is well-know, also less appreciated are the alpha cells which are implicated in the faulty response (or lack thereof) to insulin induced hypoglycemia, and as you note, delta cells, also largely ignored.
Diabetes (all types) is one of the few diseases where there is little focus not on the root cause, yet a flawed fixation on the end result, namely glycemic management. For those who suffer from hypoglycemia unawareness, we'd also like to see some more research into faulty alpha cells which are damaged permanently by autoimmunity; as insulin replacement is a dangerous juggling act on a tightrope without the net to catch us if (or when) we fall!
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Scott,
I am in total agreement with you!
The more insulin someone takes, the more of a challenge it becomes. There are so many pieces of the puzzle to solve.
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All I can say is WoW....always wonderful to learn something new everytime I come!
Love it!
Keep Pressin' on!!!
Hugs
Jaimie
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Allie--
Great post. BTW, I'm still looking for a good endocrinologist . . . are you available? This post reminds me of a multitude of chronic diseases which are unexplained complexities of our individual makeup. Isolating, at the cellular level, may only reflect the total genetic makeup of that cell--not the entire population. Only when you isolate that same cell from a large population suffering the same chronic disease can you be sure results are reflective of the total population experiencing the disease.
Outcome-based treatment doesn't care to ask the question of the total population. They want only to treat the symptomology of one cell.
As I have stated previously, if our caregivers and medical schools would think about the complexities of our disease as assiduously as we all do, maybe we would be closer to a cure.
Remember, the medical community surrounding Boston still is our brightest beacon, so I would alter the close of your fourth paragraph--GO PATS!!!
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Posted by Scott Strumello on Tuesday 22 January 2008
> 0108 www.tinyurl.com/2sm83k [LoveDiabetes.com]
"...You make a good point, namely because most researchers are fixated on beta cells ... less appreciated are the alpha cells which are implicated in the faulty response (or lack thereof) to insulin induced hypoglycemia, and as you note, delta cells, also largely ignored..."
Hi Scott & AnyOne else,
Pancreas contains at least 5 types of endocrine cells ... A, B, C, D & E
In Greek that is alpha, beta, gamma, delta & epsilon.
Alpha-cells & Epsilon-cells (www.tinyurl.com/2psoy3) secrete ghrelin which inhibits beta-cell insulin release & stimulates growth hormone release from the anterior pituitary (www.tinyurl.com/3exose) AND alpha-cells secrete glucagon which stimulates glucose production in / release from ... the LIVER ... into the blood. Delta-cells secrete somatostatin which 'depresses' functionality of the thyroid / alpha / beta & epsilon cells to help prevent growth hormone induced relative-HYPOglycemia. The amount of alpha-cell glucagon release is apparently reduced by beta-cell amylin release AND the insulin/glucagon ratio ... so the amount & type of insulin [from the beta-cells or 'injected'] can have a substantial effect upon how alpha-cell glucagon protects from relative-HYPOglycemia ... which otherwise stimulates the gamma cells to produce P-peptide and apparently VI-peptide which appears to orchestrate a natural colonic detox flush ... as needs be [all c/o the LOVE / protector hormone ... ADRENALINE (www.tinyurl.com/2pfp6a)]
There is a different outcome between alpha-cell glucagon ... stimulated relative-HYPERglycemia [EG a horror movie (www.tinyurl.com/2opc5h)] & eating too OFTEN ... caused acute relative-HYPERglycemia [EG a cake (www.tinyurl.com/32dvnb)]
Chronic relative-HYPERglycemia causes down-regulation auto-immunity of the alpha-cells.
> 1098 www.tinyurl.com/2b8mpf [mikael.knip@hus.fi ~ type1A down-regulation auto-immunity of alpha-cells continues after GM insulin ... in Children]
There is a different outcome between beta-cell insulin ... stimulated relative-HYPOglycemia [EG type 2] & eating too OFTEN + growth hormone ... caused acute relative-HYPOglycemia [EG type 1A]
> 1006 www.tinyurl.com/3e2qzk [Johnny.Ludvigsson@lio.se ~ Ludvigsson HYPOthesis / rapid growth]
Chronic relative-HYPOglycemia-distress causes down-regulation auto-immunity of the beta-cells.
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu ~ type1A down-regulation auto-immunity of the beta-cells continues after GM insulin ... in NOD mice]
> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / Eating too OFTEN = Relative-HYPOglycemia-distress = diabetes]
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.24.JAN.2008 @ 19:01hrs c/o www.DiabetesHealth.com/read/2007/11/29/5564.html
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
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Allie - a very interesting post.
What caught my attention was the focus of thinking on a whole-body level, not just beta cells or delta cells, etc. - that it's all interconnected. It is interconnected - it's energy. Biology 101 needs a serious update to reflect quantum physics. (For those unfamiliar with the concept, "mass" isn't. The closer you look at anything, all that you see is swirling energy. Nothing is "solid". Today's medical approach still behaves as if it is. Energy affects energy.)
If you're interested in exploring this topic further, I'd highly recommend a book called The Biology of Belief by Bruce Lipton. Minus the epilogue, which I can't recommend, it's realigned my thinking about diabetes or any dis-ease completely. The interconnectedness of cellular function IS critical here. It's not just beta cells, or delta cells, though, it's the fluidity of energy between all cells and how the mind affects the whole. Screw up the connectivity and dis-ease results. The kicker though is that the mind CAN effect change. There's also a companion DVD called The Biology of Perception that is a very good "see-ahead" (of reading the book.) (Sidenote: I have no affiliation or vested interest in recommending either of these.)
As a sidenote, I also don't necessarily buy the concept so widely and mindlessly accepted that Type 1 diabetes is an auto-immunity problem that the body starts, then effectively turns on itself. It doesn't make sense evolutionarily. To me, it sounds like a classic western medicine cop-out ("if you don't understand it, blame the patient (i.e. it's genetics.") But genes don't control cellular function. Take away the DNA and cells continue to live just fine.
Who's to say that most diabetic conditions are not caused by environmental toxins that effect all cells - beta, delta, alpha, etc. - but that some are affected more than others, and more specifically more on those that "hit" glucose regulation? Assuming the opposite - that it's always the patient's fault, aka genetics - has never been proven. Set up the "right" environment (no breastfeeding, early cereal introduction, vaccinations, pollution, etc.) and introduce a trigger to screw up intercellular connectivity that targets glucose regulation and whammo, hyperglycemia. Treat hyperglycemia with exogenous insulin, and whammo, insulin-dependent diabetes and a cash cow for pharmaceutical industry.
Anyway, for what it's worth - read this book.
Kelly
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DR COUSENS' NEW CURE FOR TYPE 1
DIABETES & TYPE 2 DIABETES...
> 0108 www.tinyurl.com/3yzsyx [Dr Gabriel Cousens ~ page xxiv & page 363 documents CURE within 14 days for type 1 Diabetic subsequently GM insulin-free for some 2 years following that CURE for type 1 diabetes].
CAUSE OF DIABETES ...
Eating too OFTEN = Relative-HYPOglycemia-distress = diabetes
3 LAYERS OF EVIDENCE...
In the light of: Harry Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Michael Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research AND ... George Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable NOW is the 2007 Gracey HYPOthesis for the CAUSE & CURE of diabetes(?)...
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.tinyurl.com/2uxb99 [Dr Allan Cott c/o Dr Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Dr Michael Dosch]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].
> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / Relative-HYPOglycemia DISTRESS ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical ... Please study that HYPO-thesis link, very CAREfully, and communicate any genuine questions / positivising suggestions by email].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.25.JAN.2008 @ 19:23hrs c/o DiabetesHealth.com
"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
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Very interesting article, thanks for sharing.
I'm pretty new to the whole diabetes thing, so I had a little trouble following what you were saying. Of course it may also be because I'm not a football fan too :o)
I know this isn't the point you were trying to make, but the first thing that struck me is that you said the Delta cells inhibit growth hormone. My newly dx'ed 2 year old is extremely tall ... and her dad and I are not. She's like in the 99th percentile for height in her age group, she's as tall as a 4 year old. Is her type 1 responsible for that?
I apologize if I'm just stating the obvious. It's been a rough couple of months, and my daughter's endocrinologist isn't very forthcoming with non-vital information.
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FECES PUTREFACTION INCREASES T1 & T2 AUTO-IMMUNITY
JUICE BAR OR 'SOLIDS' RESTAURANT ?
> 1207 www.tinyurl.com/2akmba [American Colon Therapy Association ~ '...undigested food molecules act as antigens, foreign substances that provoke an immune reaction...']
> 1207 www.Liquidiet.info [May compliment pancreatic VI-peptide (www.tinyurl.com/yrd6uu)]
WHY?
5 LAYERS OF EVIDENCE...
In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Rosenbloom's 2000 re-hydration controversy, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom].
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].
Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...
> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].
…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.09.FEB.2008 @ 20:40hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
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"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-NormoGlycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPERglycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-NormoGlycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODc) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... relative-HYPOglycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
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