Welcome to Allies Voice - Voicing the issue with Diabetes
Allison Love Beatty, a former blogger on AOL's The Diabetes Blog, continues voicing the issue with diabetes - now on YouTube! She's raising the issue on topics like: the cure for diabetes, the quest for c-peptide, genetically modifined insulins, the absence of insulin choice, and numerous other issues affecting the quality of life for people like her living with diabetes.
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- See what Allie'sbeen blogging about on The Diabetes Blog
- What is Dr. Faustman's Cure for Type 1 Diabetes?
Human trials beginning December 2007 - and Allie's scheduled for April 22, 2008!!!
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11/16/2007 12:41 PM
krunitomul blog wrote:
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Hello Allison,
Thank you for your attempt to get this message out. I was interviewed by the IndyStar regarding Eli Lilly discontinuing the Animal Insulin and their position has been that everyone can take Humilin or Humilog and just go see your doctor. Google Indystar and my name and you can read the article. The message is out there but no one will listen. People with new case of this condition have no idea what the real issue is and just assume that this is part of the condition. Keep trying but big money and the lack of concern is really hard to get over. Do you import and if so, I would like to talk to you regarding ways we can work together to get this situtation resolved for people like us. Please feel free to e-mail me at Glennv411@hotmail.com or call me at 714-349-1963 cell number. Thank you for your attemps and keep up the good work we need all the help we can get. Thank you for your help. Glenn
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Hi Allie,
It was great speaking with you on Tuesday regarding diabetes. I sent you the cd on Omega 3 Basic for your review. I'd like to keep in touch.
Best Wishes,
Ginger Singer
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Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2007;13(2):95-8.Related Articles, Links
[Proinsulin C-peptide -- the bioactive peptide with a huge promise]
[Article in Polish]
Walenciak Ł, Fendler W, Młynarski W.
Klinika Chorób Dzieci I Katedry Pediatrii UM w Łodzi.
Proinsulin connecting peptide (C-peptide) has been initially regarded as deprived of biological functions other than correct scaffolding of insulin. This was caused by the lack of evident effect of C-peptide administration to healthy subjects or animals. At present, in view of numerous studies concerning its structure, membrane binding and biological functions, C-peptide seems to constitute a crucial role in the pathogenesis of complications in diabetes mellitus type 1 (DM1). Patients who maintain high remnant insulin secretion (and therefore also of C-peptide) develop complications such as nephropathy, neuropathy and later microangiopathy with a milder clinical course. In this article we have covered molecular and cellular aspects of C-peptide functioning, such as: activation of protein kinase C, Na+,K+- ATP-ase, nitric oxide synthase, MAP and ERK 1/2 kinases, improvement of nerve conduction velocity and interactions with exogenous and endogenous insulin. We also outline the clinical consequences of deficiency of this underestimated peptide along with its potential therapeutical possibilities in the primary and secondary prevention of DM1 complications.
Publication Types:
English Abstract
Review
PMID: 17880815 [PubMed - indexed for MEDLINE]
Reply to this
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2007;13(2):95-8.Related Articles, Links
[Proinsulin C-peptide -- the bioactive peptide with a huge promise]
[Article in Polish]
Walenciak Ł, Fendler W, Młynarski W.
Klinika Chorób Dzieci I Katedry Pediatrii UM w Łodzi.
Proinsulin connecting peptide (C-peptide) has been initially regarded as deprived of biological functions other than correct scaffolding of insulin. This was caused by the lack of evident effect of C-peptide administration to healthy subjects or animals. At present, in view of numerous studies concerning its structure, membrane binding and biological functions, C-peptide seems to constitute a crucial role in the pathogenesis of complications in diabetes mellitus type 1 (DM1). Patients who maintain high remnant insulin secretion (and therefore also of C-peptide) develop complications such as nephropathy, neuropathy and later microangiopathy with a milder clinical course. In this article we have covered molecular and cellular aspects of C-peptide functioning, such as: activation of protein kinase C, Na+,K+- ATP-ase, nitric oxide synthase, MAP and ERK 1/2 kinases, improvement of nerve conduction velocity and interactions with exogenous and endogenous insulin. We also outline the clinical consequences of deficiency of this underestimated peptide along with its potential therapeutical possibilities in the primary and secondary prevention of DM1 complications.
Publication Types:
English Abstract
Review
PMID: 17880815 [PubMed - indexed for MEDLINE]
Reply to this
Hi Seale Harris, Martin Buehler, Harry Salzer, Robert Tanenberg, anonymous, AllieB2, ricklude, Allison Love Beatty, Melody, Brent, Billy Warhol, Scott, BetterCell, Glenn, Jenny, David Beatty, bird54, Ladybird, Nick Trubov, Ron Rosedale, Diana Karaffa, Lissa Coffey, John Manley, Bill Corey, MEC, Harry Thompson, Nicholas Rheinberg, Brian Rodgers, Scott King, Linda von Wartburg, Nadia Al-Samarrie & AnyOne else...
Posted by anonymous on 29 November 2007:-
"... I'm a type-2 who recently started once-a-day insulin, using the Pen. ... As to dosing, one can start with a base dosage of slow-acting and up it or lower it based on BG reading. ... The one issue I'm still working on is matching my dose to my BG reading and "getting my number down".
www.DiabetesHealth.com/read/2007/11/29/5564.html
Hi anonymous,
The CAUSE of diabetes is eating too often ... so the body maintains an above-average blood glucose to prevent nerve/brain damage which happens when a Person is getting a blood glucose "number down" too quickly ie the body is protecting nerve/brain cells from the consequences of "relative-HYPOglycemia" [first recognized in 1924]...
... 1924 Harris. S, "Hyperinsulinism and Dysinsulinism", J.A.M.A 83: 729-733, 1924 [Seale Harris]
Dr Juan E Grunwald's 1987 discovery suggests that a Person getting a blood glucose "number down" too quickly can cause an approximate 15% reduction in blood flow to nerve/brain tissue ... potentially starving that tissue and possibly causing it to 'switch-off' by means of oxygen starvation and/or glucose starvation [relative-HYPOglycemia].
... 1987 http://tinyurl.com/2d48d5 [ juangrun@mail.med.upenn.edu]
Depending upon the severity of a Person getting a blood glucose "number down" too quickly ... relative-HYPOglycemia can result in the following neuro-psychiatric symptoms as the body is distressed into 'corrective' methods of preventing nerve/brain tissue from switching-off ...
Depression, Insomnia, Anxiety, Irritability, Crying Spells, Phobias, Lack of Concentration, Forgetfulness or Confusion, Unsocial or Antisocial Behavior, Restlessness, Psychosis, Suicidal Behavior; Exhaustion or Fatigue, Sweating, Tachycardia, Anorexia, Chronic Indigestion or Bloating, Cold Hands or Feet, Joint Pains, Obesity, Abdominal Spasm; Headache, Dizziness, Tremor [inward or external], Muscle Pains & Backache, Numbness, Blurred Vision, Muscular Twitching or Cramps, Staggering, Fainting or Blackouts and also Convulsions.
... 1966 'Relative-HYPOglycemia As A Cause Of Neuropsychiatric Illness' @ Journal Of The National Medical Association @ Harry M Salzer MD @ January 1966 @ Vol 58 @ Number 1 @ Table 1 @ Figure 2.
Continued ...
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Continued ...
In 1996 Dr Maurizio Vanelli discovered that relative-HYPOglycemia, aka getting a blood glucose "number down" too quickly, can ALSO result in "hemolytic anemia" ... a discovery that was supported by Dr Francesca Messina's 2004 research.
... 1996 http://tinyurl.com/24rzbf [ maurizio.vanelli@unipr.it]
... 2004 http://tinyurl.com/2gcjdn [ francesca_messina@yahoo.it]
Since 1924 ... research has been underway to better determine the role of relative-HYPOglycemia associated 'sudden hemolytic anemia' aka 'exploded & fragmented' red blood cells ... in sudden blood clots appearing in the veins / brain / heart aka dvt [deep vein thrombosis] / stroke [aka cerebral infarction] / heart attack [aka myocardial infarction].
... 2006 http://tinyurl.com/2h68by [ benbloom@mail.com]
... 2006 http://tinyurl.com/2gcqnu [ stefan.herget-rosenthal@uni-essen.de]
... 2007 http://en.wikipedia.org/wiki/Anti-diabetic_drug
... 2007 http://en.wikipedia.org/wiki/Hemolysis
... 2007 http://en.wikipedia.org/wiki/Hemolytic_anemia
... 2007 http://en.wikipedia.org/wiki/Coagulation
... 2007 http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura
The CURE for diabetes is drinking water more OFTEN and eating LESS often.
Indigestion [of excess blood glucose] is Caused By Food And Or Drug Administration Too Much And Or Too Often.
Inflammation / Indigestion is caused by cellular over-load ... which occurs at different times in different People depending upon their 'Powers of DIGESTION' at any given time.
Eating less often can CURE both indigestion & inflammation.
Eating less is profoundly different from eating less OFTEN.
HYPERglycemia aka excess blood glucose aka excess blood carbohydrate ... is a symptom of indigestion / inflammation.
There is ZERO requirement for any carbohydrate by Human Beings.
UNdrugTREATED type 2 Diabetics can handle plenty of carbohydrate ... They need to drink more water because they 'handle' excess carbohydrate simply by urinating excess glucose [water-soluble] just like People urinate excess water-soluble vitamins.
UNdrugTREATED type 2 Diabetics and other healthy People should test daily with ChemStrips and pause from eating, and drink just water, until their urine is glucose free. The less carbohydrate eaten ... the less time between meals.
That is how to CURE type 2 diabetes and prevent all 'newly diagnosed' type 1 & type 2 diabetes.
Eating less is profoundly different from eating less OFTEN.
... 2000 http://tinyurl.com/2j7p3t [ dfadool@neuro.fsu.edu]
... 2001 http://tinyurl.com/yqf8gj [ maeda@ys7.u-shizuoka-ken.ac.jp]
... 2003 http://tinyurl.com/ys63gk [ anson@jhu.edu]
... 2007 http://tinyurl.com/3aypqg [ mristow@mristow.org]
Continued ...
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Continued ...
In respect of the opinions above ... please AnyOne ... ALSO ask your current Specialist for advice including the provision of supporting Peer reviewed references evidencing their understanding of this important matter.
... http://tinyurl.com/2vp4e9">http://tinyurl.com/2vp4e9 [DrBernarr@aol.com]
…Warm thanks; Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.DiabetesHealth.com @ 10:33hrs WED.12.DEC.2007.
www.DiabetesHealth.com/read/2007/12/03/5558.html
http://HealSelf.org/Diabetes.html [DrBernarr@aol.com]
www.DiabetesHealth.com/read/2007/11/29/5564.html
2007 http://en.wikipedia.org/wiki/Hyperglycemia
1924 Harris. S, "Hyperinsulinism and Dysinsulinism", J.A.M.A 83: 729-733, 1924 [Seale Harris]
1987 http://tinyurl.com/2d48d5 [juangrun@mail.med.upenn.edu]
1966 'Relative-HYPOglycemia As A Cause Of Neuropsychiatric Illness' @ Journal Of The National Medical Association @ Harry M Salzer MD @ January 1966 @ Vol 58 @ Number 1 @ Table 1 @ Figure 2 [Harry Salzer]
1996 http://tinyurl.com/24rzbf [maurizio.vanelli@unipr.it]
2004 http://tinyurl.com/2gcjdn [francesca_messina@yahoo.it]
2007 http://en.wikipedia.org/wiki/Hemolysis
2007 http://en.wikipedia.org/wiki/Hemolytic_anemia
2007 http://en.wikipedia.org/wiki/Coagulation
2007 http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura
2000 http://tinyurl.com/2j7p3t [dfadool@neuro.fsu.edu]
2001 http://tinyurl.com/yqf8gj [maeda@ys7.u-shizuoka-ken.ac.jp]
2003 http://tinyurl.com/ys63gk [anson@jhu.edu]
2007 http://tinyurl.com/3aypqg [mristow@mristow.org]
2007 http://tinyurl.com/2vp4e9">http://tinyurl.com/2vp4e9 [DrBernarr@aol.com]
.
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Hi Robert Tanenberg, anonymous, ricklude, Allison Love Beatty, Melody, Brent, Billy Warhol, Scott, BetterCell, Glenn, Jenny, David Beatty, bird54, Ladybird, Nick Trubov, Ron Rosedale, Diana Karaffa, Lissa Coffey, John Manley, Bill Corey, MEC, ginger singer, Nicole Manley, Harry Thompson, Nicholas Rheinberg, Brian Rodgers, Scott King, Linda von Wartburg, Nadia Al-Samarrie & AnyOne else...
More questions re. Relative-HYPOglycemia / strokes / heart attacks ...
Following the introduction of commercial insulin in 1923 ... in 1924 both 'relative-HYPOglycemia' and BIG stroke / heart attack inducing blood clots became 'mortuary news'.
... 2003 http://tinyurl.com/2owwsn [skarch@sonic.net]
'Exploding' red blood cells [RBC] and/or 'exploding' arterial lining-cells [ALC] following relative-HYPOglycemia is a chemistry issue ... OSMOSIS ... [plasma blood glucose] falls faster than [intracellular RBC & ALC glucose] following HYPOglycemic drug/food/chemical distress ... ' WATER-bomb' RBC & 'WATER-zit' ALC 'explode' [aka hemolysis] during osmotic correction ie RBC & ALC edema [as per the brain & heart failure mechanism] ... fragmented ALC and/or fragmented RBC = circulating clot material = infarction eg @ ALC 'explosion' site.
... 2007 http://en.wikipedia.org/wiki/Image:Osmotic_pressure_on_blood_cells_diagram.svg
The same osmotic correction, following relative-HYPOglycemia, also leads to nerve/brain edema and/or the heart failure 'heart-overloading' tissue edema mechanism as WATER is osmotically 'pumped' into the interstitial fluid / cerebro-spinal fluid [over-loading the heart's capacity to overcome the extra RESISTANCE from the WATER-logged body].
... 2007 http://en.wikipedia.org/wiki/Osmosis
... 2007 http://en.wikipedia.org/wiki/Interstitial_fluid
Any comment/s ... upon the possible mechanistic association between infarctions & 'sudden hemolytic anemia' following relative-HYPOglycemia associated distress [eg including GM insulin induced' vasoCONSTRICTION'] ... would be appreciated.
... 1987 http://tinyurl.com/2d48d5 [juangrun@mail.med.upenn.edu]
Please review my WED.12.DEC.2007 comment [above], in reply to anonymous' 29 November 2007 comment ... including linked references within that reply.
In respect of the opinions above ... please AnyOne ... ALSO ask your current Specialist for advice including the provision of supporting Peer reviewed references evidencing their understanding of this important matter.
... 2007 http://tinyurl.com/2vp4e9 [DrBernarr@aol.com]
…Warm thanks; Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.AlliesVoice.com @ 10:32hrs THU.13.DEC.2007.
www.DiabetesHealth.com/read/2007/12/03/5558.html
http://HealSelf.org/Diabetes.html [DrBernarr@aol.com]
www.DiabetesHealth.com/read/2007/11/29/5564.html
2007 http://en.wikipedia.org/wiki/Hyperglycemia
1924 Harris. S, "Hyperinsulinism and Dysinsulinism", J.A.M.A 83: 729-733, 1924 [Seale Harris]
2007 http://tinyurl.com/29kvda [zangend@hadassah.org.il]
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